Consensus statement on the pathology of IgG4-related disease

被引：1812

作者：

Deshpande, Vikram ^{[1
]}

Zen, Yoh ^{[2
]}

Chan, John K. ^{[3
]}

Yi, Eunhee E. ^{[4
]}

Sato, Yasuharu ^{[5
]}

Yoshino, Tadashi ^{[5
]}

Kloeppel, Guenter ^{[6
]}

Heathcote, J. Godfrey ^{[7
]}

Khosroshahi, Arezou ^{[8
]}

Ferry, Judith A. ^{[1
]}

Aalberse, Rob C. ^{[9
]}

Bloch, Donald B. ^{[8
]}

Brugge, William R. ^{[10
]}

Bateman, Adrian C. ^{[11
]}

Carruthers, Mollie N. ^{[8
]}

Chari, Suresh T. ^{[12
]}

Cheuk, Wah ^{[3
]}

Cornell, Lynn D. ^{[13
]}

Fernandez-Del Castillo, Carlos ^{[14
]}

Forcione, David G. ^{[10
]}

Hamilos, Daniel L. ^{[19
]}

Kamisawa, Terumi ^{[15
]}

Kasashima, Satomi ^{[16
]}

Kawa, Shigeyuki ^{[17
]}

Kawano, Mitsuhiro ^{[18
]}

Lauwers, Gregory Y. ^{[1
]}

Masaki, Yasufumi ^{[20
]}

Nakanuma, Yasuni ^{[21
]}

Notohara, Kenji ^{[22
]}

Okazaki, Kazuich ^{[23
]}

Ryu, Ji Kon ^{[24
]}

Saeki, Takako ^{[25
]}

Sahani, Dushyant V. ^{[26
]}

Smyrk, Thomas C. ^{[13
]}

Stone, James R. ^{[1
]}

Takahira, Masayuki ^{[27
]}

Webster, George J. ^{[28
]}

Yamamoto, Motohisa ^{[29
]}

Zamboni, Giuseppe ^{[30
]}

Umehara, Hisanori ^{[20
]}

Stone, John H. ^{[8
]}

机构：

[1] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[2] Kings Coll Hosp London, Inst Liver Studies, London SE5 8RX, England

[3] Queen Elizabeth Hosp, Dept Pathol, Kowloon, Hong Kong, Peoples R China

[4] Mayo Clin, Div Anat Pathol, Rochester, MN USA

[5] Okayama Univ, Dept Pathol, Grad Sch Med Dent & Pharmaceut Sci, Okayama 7008530, Japan

[6] Tech Univ Munich, Dept Pathol, Munich, Germany

[7] Dalhousie Univ, Dept Pathol, Halifax, NS, Canada

[8] Massachusetts Gen Hosp, Rheumatol Unit, Boston, MA 02114 USA

[9] Univ Amsterdam, Dept Immunol, Amsterdam, Netherlands

[10] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA

[11] Southampton Gen Hosp, Dept Cellular Pathol, Southampton SO9 4XY, Hants, England

[12] Mayo Clin Fdn, Div Gastroenterol, Rochester, MN USA

[13] Mayo Clin Fdn, Dept Pathol, Rochester, MN USA

[14] Massachusetts Gen Hosp, Dept Surg, Boston, MA 02114 USA

[15] Tokyo Metropolitan Komagome Hosp, Div Gastroenterol, Tokyo, Japan

[16] Kanazawa Med Ctr, Dept Pathol, Kanazawa, Ishikawa, Japan

[17] Shinshu Univ, Ctr Hlth Safety & Environm, Shinshu, Japan

[18] Kanazawa Univ, Div Nephrol, Grad Sch Med, Kanazawa, Ishikawa, Japan

[19] Massachusetts Gen Hosp, Div Allergy & Immunol, Boston, MA 02114 USA

[20] Kanazawa Med Univ, Div Hematol & Immunol, Kanazawa, Ishikawa, Japan

[21] Kanazawa Univ, Dept Pathol, Kanazawa, Ishikawa, Japan

[22] Kurashiki Cent Hosp, Dept Pathol, Kurashiki, Okayama, Japan

[23] Kansai Med Univ, Div Gastroenterol & Hepatol, Kansai, Japan

[24] Seoul Natl Univ, Coll Med, Div Gastroenterol, Seoul, South Korea

[25] Nagaoka Red Cross Hosp, Div Nephrol, Nagaoka, Niigata, Japan

[26] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA

[27] Kanazawa Univ, Grad Sch Med Sci, Dept Ophthalmol, Kanazawa, Ishikawa, Japan

[28] Univ Coll London Hosp, Div Gastroenterol, London, England

[29] Sapporo Med Univ, Sch Med, Dept Internal Med 1, Sapporo, Hokkaido, Japan

[30] Univ Verona, Dept Pathol, I-37100 Verona, Italy

来源：

MODERN PATHOLOGY | 2012年 / 25卷 / 09期

关键词：

consensus statement; IgG4; IgG4-related disease; IGG4-POSITIVE PLASMA-CELLS; HEPATIC INFLAMMATORY PSEUDOTUMOR; AUTOIMMUNE PANCREATITIS; SCLEROSING CHOLANGITIS; DIAGNOSTIC-CRITERIA; SYSTEMIC-DISEASE; RETROPERITONEAL FIBROSIS; IGG4; FEATURES; BIOPSY;

D O I：

10.1038/modpathol.2012.72

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

IgG4-related disease is a newly recognized fibro-inflammatory condition characterized by several features: a tendency to form tumefactive lesions in multiple sites; a characteristic histopathological appearance; and-often but not always-elevated serum IgG4 concentrations. An international symposium on IgG4-related disease was held in Boston, MA, on 4-7 October 2011. The organizing committee comprising 35 IgG4-related disease experts from Japan, Korea, Hong Kong, the United Kingdom, Germany, Italy, Holland, Canada, and the United States, including the clinicians, pathologists, radiologists, and basic scientists. This group represents broad subspecialty expertise in pathology, rheumatology, gastroenterology, allergy, immunology, nephrology, pulmonary medicine, oncology, ophthalmology, and surgery. The histopathology of IgG4-related disease was a specific focus of the international symposium. The primary purpose of this statement is to provide practicing pathologists with a set of guidelines for the diagnosis of IgG4-related disease. The diagnosis of IgG4-related disease rests on the combined presence of the characteristic histopathological appearance and increased numbers of IgG4(+) plasma cells. The critical histopathological features are a dense lymphoplasmacytic infiltrate, a storiform pattern of fibrosis, and obliterative phlebitis. We propose a terminology scheme for the diagnosis of IgG4-related disease that is based primarily on the morphological appearance on biopsy. Tissue IgG4 counts and IgG4:IgG ratios are secondary in importance. The guidelines proposed in this statement do not supplant careful clinicopathological correlation and sound clinical judgment. As the spectrum of this disease continues to expand, we advocate the use of strict criteria for accepting newly proposed entities or sites as components of the IgG4-related disease spectrum. Modern Pathology (2012) 25, 1181-1192; doi:10.1038/modpathol.2012.72; published online 18 May 2012

引用

页码：1181 / 1192

页数：12

共 50 条

[1] Applying the consensus statement on the pathology of IgG4-related disease to lacrimal gland lesions
Andrew, Nicholas
Kearney, Daniel
Selva, Dinesh
MODERN PATHOLOGY, 2013, 26 (08) : 1150 - 1151
[2] International Consensus Guidance Statement on the Management and Treatment of IgG4-Related Disease
Khosroshahi, A.
Wallace, Z. S.
Crowe, J. L.
Akamizu, T.
Azumi, A.
Carruthers, M. N.
Chari, S. T.
Della-Torre, E.
Frulloni, L.
Goto, H.
Hart, P. A.
Kamisawa, T.
Kawa, S.
Kawano, M.
Kim, M. H.
Kodama, Y.
Kubota, K.
Lerch, M. M.
Lohr, M.
Masaki, Y.
Matsui, S.
Mimori, T.
Nakamura, S.
Nakazawa, T.
Ohara, H.
Okazaki, K.
Ryu, J. H.
Saeki, T.
Schleinitz, N.
Shimatsu, A.
Shimosegawa, T.
Takahashi, H.
Takahira, M.
Tanaka, A.
Topazian, M.
Umehara, H.
Webster, G. J.
Witzig, T. E.
Yamamoto, M.
Zhang, W.
Chiba, T.
Stone, J. H.
ARTHRITIS & RHEUMATOLOGY, 2015, 67 (07) : 1688 - 1699
[3] Gallbladder Pathology in IgG4-Related Sclerosing Disease
Bagci, P.
Saka, B.
Dursun, N.
Basturk, O.
Bandyopadhyay, S.
Jang, K-T
Kong, S. Y.
Goodman, M.
Farris, A. B.
Krasinskas, A.
Zen, Y.
Tapia, O. E.
Roa, J. C.
Farris, A. B.
Adsay, V.
LABORATORY INVESTIGATION, 2012, 92 : 440A - 441A
[4] Gallbladder Pathology in IgG4-Related Sclerosing Disease
Bagci, P.
Saka, B.
Dursun, N.
Basturk, O.
Bandyopadhyay, S.
Jang, K-T
Kong, S. Y.
Goodman, M.
Farris, A. B.
Krasinskas, A.
Zen, Y.
Tapia, O. E.
Roa, J. C.
Farris, A. B.
Adsay, V.
MODERN PATHOLOGY, 2012, 25 : 440A - 441A
[5] CHARACTERISTIC PATHOLOGY OF IgG4-RELATED KIDNEY DISEASE
Michio, Nagata
Satoshi, Hara
Ichiro, Mizushima
Mitsuhiro, Kawano
Takako, Saeki
Yoshifumi, Ubara
Nobuya, Ohara
Yasuharu, Sato
Kazunori, Yamada
Hitoshi, Nakashima
Shinichi, Nishi
Yutaka, Yamaguchi
Satoshi, Hisano
Nobuaki, Yamanaka
Takao, Saito
NEPHROLOGY, 2014, 19 : 11 - 12
[6] OVERVIEW: IgG4-RELATED DISEASE AND IgG4-RELATED KIDNEY DISEASE
Mitsuhiro, Kawano
NEPHROLOGY, 2014, 19 : 11 - 11
[7] Histopathology of IgG4-Related Autoimmune Hepatitis and IgG4-Related Hepatopathy in IgG4-Related Disease
Nakanuma, Yasuni
Ishizu, Yoji
Zen, Yoh
Harada, Kenichi
Umemura, Takeji
SEMINARS IN LIVER DISEASE, 2016, 36 (03) : 229 - 241
[8] The pathology of IgG4-related disease: critical issues and challenges
Deshpande, Vikram
SEMINARS IN DIAGNOSTIC PATHOLOGY, 2012, 29 (04) : 191 - 196
[9] The Pathology of IgG4-Related Disease in the Bile Duct and Pancreas
Zen, Yoh
SEMINARS IN LIVER DISEASE, 2016, 36 (03) : 242 - 256
[10] IgG4-Related Disease
Leporati, Paola
Fonte, Rodolfo
Chiovato, Luca
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (17): : 1645 - 1645

← 1 2 3 4 5 →