Cardiovascular effects of incretin-based therapies

被引：0
|
作者：
Lehrke, M. [1 ]
Marx, N. [1 ]
机构：
[1] Univ Klinikum Aachen, Med Klin Kardiol Pneumol & Angiol 1, D-52074 Aachen, Germany
来源：
HERZ | 2012年 / 37卷 / 03期
关键词：
Incretin; Glucagon-like peptide 1 (GLP-1); Myocardial infarction; Heart failure; GLUCAGON-LIKE PEPTIDE-1; ISCHEMIA-REPERFUSION INJURY; MYOCARDIAL GLUCOSE-UPTAKE; LEFT-VENTRICULAR PERFORMANCE; CONSCIOUS DOGS; BLOOD-PRESSURE; CARDIAC-FUNCTION; 7-36; AMIDE; ENDOTHELIAL FUNCTION; DOBUTAMINE STRESS;
D O I：
10.1007/s00059-012-3599-8
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Pharmacological modulation of the glucagon-like peptide-1 (GLP-1) system has emerged as a new therapeutic option for treatment of diabetes mellitus. In addition to the glucose lowering potential GLP-1 was found to have a variety of cardioprotective effects. GLP-1 reduced the size of myocardial infarction during acute ischemia by activation of prosurvival pathways including PI3-kinase, Akt und ERK1/2. In addition, GLP-1 prevented atherosclerotic lesion formation in experimental models and improved endothelial function while acting anti-inflammatory. Furthermore GLP-1 was found to improve chronic heart failure by increasing insulin independent cellular glucose transport. Consequently GLP-1 based therapies might reduce cardiovascular events in diabetic patients which is currently evaluated in clinical endpoint studies.
引用
收藏
页码：287 / 293
页数：7
相关论文
共 50 条
  • [1] Cardiovascular Effects of Incretin-Based Therapies
    White, William B.
    Baker, William L.
    ANNUAL REVIEW OF MEDICINE, VOL 67, 2016, 67 : 245 - 260
  • [2] Potential cardiovascular effects of incretin-based therapies
    Deacon, Carolyn F.
    Marx, Nikolaus
    EXPERT REVIEW OF CARDIOVASCULAR THERAPY, 2012, 10 (03) : 337 - 351
  • [3] Cardiovascular Actions of Incretin-Based Therapies
    Ussher, John R.
    Drucker, Daniel J.
    CIRCULATION RESEARCH, 2014, 114 (11) : 1788 - 1803
  • [4] Incretin-based therapies and cardiovascular risk
    Mannucci, Edoardo
    Dicembrini, Ilaria
    CURRENT MEDICAL RESEARCH AND OPINION, 2012, 28 (05) : 715 - 721
  • [5] Beyond Glycemic Control: Cardiovascular Effects of Incretin-Based Therapies
    Angeli, Franca S.
    Shannon, Richard P.
    CARDIOVASCULAR ISSUES IN ENDOCRINOLOGY, 2014, 43 : 144 - 157
  • [6] Implications of incretin-based therapies on cardiovascular disease
    Rotz, M. E.
    Ganetsky, V. S.
    Sen, S.
    Thomas, T. F.
    INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2015, 69 (05) : 531 - 549
  • [7] Cardiovascular Effects of Incretin-Based Therapies: Integrating Mechanisms With Cardiovascular Outcome Trials
    Ussher, John R.
    Greenwell, Amanda A.
    Nguyen, My-Anh
    Mulvihill, Erin E.
    DIABETES, 2022, 71 (02) : 173 - 183
  • [8] Incretin-Based Therapies
    Neumiller, Joshua J.
    MEDICAL CLINICS OF NORTH AMERICA, 2015, 99 (01) : 107 - +
  • [9] The cardiovascular safety of incretin-based therapies: a review of the evidence
    John R Petrie
    Cardiovascular Diabetology, 12
  • [10] Incretin-based therapies
    Gallwitz, B.
    DIABETOLOGE, 2013, 9 (04): : 283 - +
12345