One-Pot, Two-Step Conversion of Aldehydes to Phosphonyl- and Sulfonylpyrazoles Using Bestmann-Ohira Reagent

被引：63

作者：

Kumar, Rahul ^{[1
]}

Verma, Deepti ^{[1
]}

Mobin, Shaikh M. ^{[2
]}

Namboothiri, Irishi N. N. ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Bombay 400076, Maharashtra, India

[2] Indian Inst Technol, Natl Single Crystal Xray Diffract Facil, Bombay 400076, Maharashtra, India

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 16期

关键词：

BASE-MEDIATED REACTION; REGIOSELECTIVE SYNTHESIS; DIAZOCARBONYL COMPOUNDS; PYRAZOLE; CYCLOADDITION; DERIVATIVES; CHEMISTRY; DIAZOALKANES; NITROALKENES; COMPLEXES;

D O I：

10.1021/ol301695e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot, two-step, three-component method for the conversion of commercially available aldehydes to phosphonylpyrazoles has been developed, demonstrating, for the first time, the dual reactivity of the Bestmann-Ohira reagent (BOR) in a single-pot transformation. This method, extended to the synthesis of sulfonylpyrazoles by employing BOR in the first step and a diazomethyl sulfone in the second step, is complementary, with regard to regioselectivity, to the previous methods for the synthesis of such functionalized pyrazoles.

引用

页码：4070 / 4073

页数：4

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