Quercitrin protects against ultraviolet B-induced cell death in vitro and in an in vivo zebrafish model

被引:58
|
作者
Yang, Hye-Mi [1 ]
Ham, Young-Min [2 ]
Yoon, Weon-Jong [2 ]
Roh, Seong Woon [1 ]
Jeon, You-Jin [3 ]
Oda, Tatsuya [4 ]
Kang, Sung-Myung [3 ]
Kang, Min-Cheol [3 ]
Kim, Eun-A [3 ]
Kim, Daekyung [1 ]
Kim, Kil-Nam [1 ]
机构
[1] Korea Basic Sci Inst KBSI, Marine Bio Res Team, Cheju 690140, South Korea
[2] Jeju Biodivers Res Inst, Cheju 699943, South Korea
[3] Jeju Natl Univ, Sch Marine Biomed Sci, Cheju 690756, South Korea
[4] Nagasaki Univ, Fac Fisheries, Div Biochem, Nagasaki 8528521, Japan
关键词
Ultraviolet (UV) B; Quercitrin (QR); Oxidative stress; Keratinocyte; Photoaging; Zebrafish; OXIDATIVE STRESS; SKIN-CANCER; DAMAGE; ANTIOXIDANT; IRRADIATION; INDUCTION; EXTRACT; MICE; FLAVONOIDS; PREVENTION;
D O I
10.1016/j.jphotobiol.2012.05.020
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Chronic exposure of skin to ultraviolet (UV) B radiation induces oxidative stress, which in turn, plays a crucial role in the induction of skin aging. The search for strategies to reverse skin aging is being constantly pursued. Here, the cytoprotective effect of quercitrin (QR) on UVB-induced cell injury in HaCaT human keratinocytes and in the zebrafish was investigated. Intracellular reactive oxygen species (ROS) generated by the exposure of HaCaT cells to UVB radiation were significantly decreased after treatment with QR, and significantly so with QR at 50 mu M. As a result, QR reduced UVB-induced cell death and apoptosis in HaCaT cells. QR similarly reduced UVB-induced ROS generation and cell death in live zebrafish. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码:126 / 131
页数:6
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