Genus Calliophis of Asiatic coral snakes: A deficiency of venom cross-reactivity and neutralization against seven regional elapid antivenoms

被引：12

作者：

Tan, Choo Hock ^{[1
]}

Liew, Jia Lee ^{[1
]}

Tan, Kae Yi ^{[2
]}

Tan, Nget Hong ^{[2
]}

机构：

[1] Univ Malaya, Fac Med, Dept Pharmacol, Kuala Lumpur 50603, Malaysia

[2] Univ Malaya, Fac Med, Dept Mol Med, Kuala Lumpur 50603, Malaysia

来源：

TOXICON | 2016年 / 121卷

关键词：

Calliophis bivirgata; Calliophis intestinalis; ELISA; Antigen binding; Antivenom; Cross-neutralization; HYDROPHIS-SCHISTOSUS; COBRA VENOM; SEA-SNAKE; BIVIRGATA; PROTEOME;

D O I：

10.1016/j.toxicon.2016.09.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Venoms of Calliophis bivirgata and Calliophis intestinalis exhibited moderate binding activities toward Neuro Bivalent Antivenom (Taiwan) but not the other six elapid monovalent or bivalent antivenoms available in the region. All antivenoms failed to neutralize C. bivirgata venom lethality in mice. The findings indicate the need to validate antivenom cross-reactivity with in vivo cross-neutralization, and imply that distinct antigens of Calliophis venoms should be incorporated in the production of a pan regional poly-specific antivenom. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：130 / 133

页数：4

共 3 条

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Kalita, Bhargab
Mukherjee, Ashis K.
TOXICON, 2018, 153 : 120 - 127

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