Non-secretory multiple myeloma: from biology to clinical management

被引:42
|
作者
Dupuis, Megan Murray [1 ]
Tuchman, Sascha A. [2 ]
机构
[1] Duke Univ, Dept Med, Durham, NC 27706 USA
[2] Univ North Carolina Chapel Hill, Lineberger Comprehens Canc Ctr, Div Hematol Oncol, 170 Manning Dr,CB 7305, Chapel Hill, NC 27599 USA
来源
ONCOTARGETS AND THERAPY | 2016年 / 9卷
关键词
multiple myeloma; non-secretory; immunoglobulin; ACUTE KIDNEY INJURY; PLASMA-CELLS; LIGHT-CHAIN; IMMUNOGLOBULIN; DISEASE; DETERMINANTS; PERSISTENT; EXPERIENCE; DIAGNOSIS; SURVIVAL;
D O I
10.2147/OTT.S122241
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Multiple myeloma (MM) is the second most common hematologic malignancy in the US. It is typically characterized by production of large amounts of defective immunoglobulin (Ig). Diagnosing MM and monitoring treatment response, including eventual relapse, are largely based on sequential measurements of Ig. However, a small subset of MM called non-secretory multiple myeloma (NSMM) produces no detectable Ig. This subset of true NSMM has become even smaller over time, as the advent of the serum free light chain assay has resulted in the majority of NSMM patients being recategorized as light-chain MM - that is, MM cells that produce only the light-chain component of Ig. True forms of NSMM, meaning MM that secretes no monoclonal proteins whatsoever, constitute a distinct entity that is reviewed; definition of NSMM using current detection methods, discuss the biology underpinning NSMM development, and share recommendations for how NSMM should be managed clinically with respect to detection, treatment, and monitoring.
引用
收藏
页码:7583 / 7590
页数:8
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