Do anti-TNF-α drugs increase cancer risk in rheumatoid arthritis patients?

被引：3
|
作者：
Clark, David A. [1 ,2 ]
机构：
[1] McMaster Univ, Dept Med, Hlth Sci Ctr Rm 3H1E, Hamilton, ON L8S 4K1, Canada
[2] Univ Toronto, Fac Med, Dept Immunol, Toronto, ON, Canada
来源：
INFLAMMOPHARMACOLOGY | 2013年 / 21卷 / 02期
关键词：
Rheumatoid arthritis; Anti-tumor necrosis factor-alpha; Cancer; Meta-analysis; NECROSIS-FACTOR INHIBITORS; MALIGNANCIES; METAANALYSIS; REGISTRY; THERAPY;
D O I：
10.1007/s10787-012-0158-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Concern has been raised about an increased risk of lymphoma and skin cancers in patients with rheumatoid arthritis due to administration of anti-TNF-alpha drugs. Meta-analysis of observational data from registries as well as from randomized controlled trials has failed to show a significant increase in the risk of lymphoma when the sample size has been sufficiently large; skin cancer risk may represent a valid concern. Issues relating to interpretation of these data are discussed.
引用
收藏
页码：125 / 127
页数：3
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