Dietary exposure of juvenile female mice to polyhalogenated seafood contaminants (HBCD, BDE-47, PCB-153, TCDD): Comparative assessment of effects in potential target tissues

被引：40

作者：

Maranghi, F. ^{[1
]}

Tassinari, R. ^{[1
]}

Moracci, G. ^{[1
]}

Altieri, I. ^{[2
]}

Rasinger, J. D. ^{[3
]}

Carroll, T. S. ^{[4
]}

Hogstrand, C. ^{[4
]}

Lundebye, A. -K. ^{[3
]}

Mantovani, A. ^{[1
]}

机构：

[1] Ist Super Sanita, Food & Vet Toxicol Unit, Vet Publ Hlth & Food Safety Dept, I-00161 Rome, Italy

[2] Ist Super Sanita, Food Chem Safety & Human Hlth Unit, Vet Publ Hlth & Food Safety Dept, I-00161 Rome, Italy

[3] Natl Inst Nutr & Seafood Res NIFES, N-5817 Bergen, Norway

[4] Kings Coll London, Diabet & Nutr Sci Div, London SE1 9NH, England

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2013年 / 56卷

关键词：

Thyroid; Thymus; Feed; Steroid hormones; Liver; POLYBROMINATED DIPHENYL ETHERS; ENHANCED HISTOPATHOLOGY; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN; HEXABROMOCYCLODODECANE; METABOLISM; EXCRETION; LESIONS;

D O I：

10.1016/j.fct.2013.02.056

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Fish represents source of nutrients and major dietary vehicle of lipophilic persistent contaminants. The study compared the effects of two legacy and two emerging fish pollutants (Hexabromocyclododecane HBCD; 2,2',4,4'-Tetrabromodiphenyl ether BDE-47; 2,2',4,4',5,5'-Hexachlorobiphenyl PCB-153; 2,3,7,8-Tetrachlorodibenzo-p-doxin TCDD) in juvenile female mice exposed through a salmon based rodent diet for 28 days (dietary doses: HBCD 199 mg/kg bw/day; BDE-47 450 mu g/kg bw/day; PCB-153 195 mu g/kg bw/day; TCDD 90 ng/kg bw/day). Dose levels were comparable to previously reported developmental Lowest Observed Adverse Effect Levels. None of the treatments elicited signs of overt toxicity, but HBCD increased relative liver weight. All compounds caused changes in liver, thymus and thyroid; spleen was affected by BDE-47 and PCB-153; no effects were seen in uterus and adrenals. Strongest effects in thyroid follicles were elicited by PCB-153, in thymus and liver by BDE-47. HBCD and BDE-47 induced liver fatty changes, but appeared to be less potent in the other tissues. HBCD, BDE-47 and TCDD increased serum testosterone levels and the testosterone/estradiol ratio, suggesting a potential involvement of pathways related to sex steroid biosynthesis and/or metabolism. The results support the role of toxicological studies on juvenile rodents in the hazard characterization of chemicals, due to endocrine and/or immune effects. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：443 / 449

页数：7

共 2 条

[1] Cross-omics gene and protein expression profiling in juvenile female mice highlights disruption of calcium and zinc signalling in the brain following dietary exposure to CB-153, BDE-47, HBCD or TCDD
Rasinger, J. D.
Carroll, T. S.
Lundebye, A. K.
Hogstrand, C.
TOXICOLOGY, 2014, 321 : 1 - 12
[2] Low dose exposure to HBCD, CB-153 or TCDD induces histopathological and hormonal effects and changes in brain protein and gene expression in juvenile female BALB/c mice
Rasinger, J. D.
Carroll, T. S.
Maranghi, F.
Tassinari, R.
Moracci, G.
Altieri, I.
Mantovani, A.
Lundebye, A. -K.
Hogstrand, C.
REPRODUCTIVE TOXICOLOGY, 2018, 80 : 105 - 116

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