Novel synthesis of heterocycles using nickel(0)-catalyzed [2+2+2] cocyclization: Catalytic asymmetric synthesis of isoindoline and isoquinoline derivatives

被引：0
|
作者：
Sato, Y
Nishimata, T
Mori, M
机构：
来源：
HETEROCYCLES | 1997年 / 44卷
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A nickel(0)-catalyzed asymmetric [2+2+2] cocyclization has been realized for the first time. That involves conceptually new enantiotopic group selective formation of the nickelacyclopentadiene (18) and produces the isoindoline (26a) (73% ee, 78% conv. yield) and isoquinoline (27b) (54% ee, 62% yield) having benzylic chiral carbon centers.
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页码：443 / 457
页数：15
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