Iridium-catalyzed enantioselective olefinic C(sp2)-H allylic alkylation

被引：15
|
作者：
Sarkar, Rahul [1 ]
Mukherjee, Santanu [1 ]
机构：
[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India
来源：
CHEMICAL SCIENCE | 2021年 / 12卷 / 08期
关键词：
CYCLOADDITION;
D O I：
10.1039/d0sc06208a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The first iridium-catalyzed enantioselective olefinic C(sp(2))-H allylic alkylation is developed in cooperation with Lewis base catalysis. This reaction, catalyzed by cinchonidine and an in situ generated cyclometalated Ir(i)/phosphoramidite complex, makes use of the latent enolate character of an alpha,beta-unsaturated carbonyl compound, namely coumalate ester, to introduce an allyl group at its alpha-position in a branched-selective manner in moderate to good yield with good to excellent enantioselectivities (up to 98 : 2 er).
引用
收藏
页码：3070 / 3075
页数：6
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