Higher levels of circulating exhausted T-cells at pre- and post-infusion negatively associated with clinical efficacy in tisagenlecleucel (Tisa-cel) treated relapsed/refractory large B-cell lymphoma (r/r LBCL) patients (pts) in JULIET trial.

被引:0
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作者
Jaeger, Ulrich [1 ]
Han, Xia [2 ]
Germano, Davide [3 ]
Quinn, David [4 ]
Gaddis, Dalia [5 ]
Masood, Aisha [2 ]
Mulvey, Tanya [4 ]
Mataraza, Jennifer [4 ]
Bishop, Michael R. [6 ]
Salles, Gilles [7 ]
Maziarz, Richard [8 ]
Schuster, Stephen [9 ]
机构
[1] Med Univ Vienna, Dept Med 1, Clin Div Hematol & Hemostaseol, Vienna Gen Hosp, Vienna, Austria
[2] Novartis Pharmaceut, E Hanover, NJ USA
[3] Novartis Pharma AG, Basel, Switzerland
[4] Novartis Inst BioMed Res, Cambridge, MA USA
[5] Navigate BioPharma Serv, Carlsbad, CA USA
[6] Univ Chicago, David & Etta Jonas Ctr Cellular Therapy, Chicago, IL 60637 USA
[7] Mem Sloan Kettering Canc Ctr, Dept Med, Lymphoma Serv, 1275 York Ave, New York, NY 10021 USA
[8] Oregon Hlth & Sci Univ, Knight Canc Inst, Portland, OR 97201 USA
[9] Univ Penn, Lymphoma Program, Abramson Canc Ctr, Philadelphia, PA 19104 USA
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中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
5186
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页数:2
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