Pre-diagnostic anti-EBV antibodies and primary liver cancer risk: a population-based nested case-control study in southern China

被引:1
|
作者
Du, Yun [1 ,2 ]
Yu, Xia [1 ]
Chang, Ellen T. [3 ]
Lian, Shifeng [4 ]
Wu, Biaohua [1 ]
Li, Fugui [1 ]
Chu, Bing [5 ]
Wei, Kuangrong [1 ]
Zhan, Jiyun [6 ]
Liang, Xuejun [6 ]
Ye, Weimin [2 ]
Ji, Mingfang [1 ]
机构
[1] Zhongshan City Peoples Hosp, Canc Res Inst Zhongshan City, Zhongshan 528400, Peoples R China
[2] Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden
[3] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA
[4] Karolinska Inst, Inst Environm Med, Unit Integrat Epidemiol, S-17177 Stockholm, Sweden
[5] Zhongshan City Peoples Hosp, Dept Pathol, Zhongshan 528400, Peoples R China
[6] Xiaolan Publ Hlth Serv Ctr, Zhongshan 528400, Peoples R China
基金
中国国家自然科学基金;
关键词
Primary liver cancer; Epstein-Barr virus; Antibody; Nested case-control study; Population-based; Epidemiology; EPSTEIN-BARR-VIRUS; HEPATOCELLULAR-CARCINOMA; HEPATITIS-B; DNA; EPIDEMIOLOGY; INFECTION; RNA;
D O I
10.1186/s12885-023-10709-5
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BackgroundWe aimed to investigate associations between pre-diagnostic anti-Epstein-Barr virus (EBV) antibodies, including interactions with hepatitis B virus (HBV), and risk of primary liver cancer in southern China.MethodsIn a population-based nested case-control study, we measured pre-diagnostic immunoglobulin A (IgA) against EBV nuclear antigen 1 (EBNA1) and viral capsid antigen (VCA) in 125 primary liver cancer cases and 2077 matched controls. We also explored the interaction between HBV surface antigen (HBsAg) and anti-EBV antibodies.ResultsParticipants with positive EBNA1-IgA, positive VCA-IgA or single-positive anti-EBV antibodies had two-fold odds of developing liver cancer, compared with seronegative subjects. The odds ratios (ORs) between the relative optical density of EBNA1-IgA and VCA-IgA and primary cancer, controlling for age and HBsAg, were 1.59 (95% confidence interval (CI): 1.17, 2.14) and 1.60 (95% CI: 1.07, 2.41), respectively. Subjects with both HBsAg and anti-EBV antibody seropositivity were at 50-fold increased risk compared with those negative for both biomarkers (OR: 50.67, 95% CI: 18.28, 140.46), yielding a relative excess risk due to interaction of 30.81 (95% CI: 3.42, 114.93).ConclusionPre-diagnostic seropositivity for EBNA1-IgA and/or VCA-IgA was positively associated with primary liver cancer risk, especially in combination with HBsAg positivity. EBV may interact with HBV in the development of primary liver cancer, and anti-EBV antibodies might be potential biomarkers for primary liver cancer in this high-risk population.
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页数:9
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