Spectrophotometric Determination of Salbutamol Sulphate and Isoxsuprine Hydrochloride in Pharmaceutical Formulations

被引：2
|
作者：
Al Abdali, Zeena Z. [1 ]
Habeeb, Nagham N. [1 ]
Salih, Elham S. [1 ]
机构：
[1] Univ Mosul, Coll Educ Pure Sci, Dept Chem, Mosul, Iraq
来源：
BAGHDAD SCIENCE JOURNAL | 2023年 / 20卷 / 02期
关键词：
Asoxsuprine hydrochloride; Evans blue dye; N-Bromosuccinamid; Salbutamol sulphate; Spectrophotometric;
D O I：
10.21123/bsj.2022.6902
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A simple, sensitive and accurate spectrophotometric method has been developed for the determination of salbutamol sulphate (SAB) and isoxsuprine hydrochloride (ISX) in pure and pharmaceutical dosage. The method involved oxidation of (SAB) and (ISX) with a known excess of N-bromosuccinamid in acidic medium, and subsequent occupation of unreacted oxidant in decolorization of Evans blue dye (EB). This, in the presence of SAB or ISX was rectilinear over the ranges 1.0-12.0, 1.0-11.0 mu g/mL, with molar absorptivity 4.21x104 and 2.58x104 l.mol-1.cm-1 respectively. The developed method had been successfully applied for the determination of the studied drugs in their pharmaceutical dosage resulting in a good agreement with certified value and standard addition procedure.
引用
收藏
页码：426 / 433
页数：8
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