Biodrug Delivery Systems: Do mRNA Lipid Nanoparticles Come of Age?

被引：6
|
作者：
Puccetti, Matteo [1 ]
Schoubben, Aurelie [1 ]
Giovagnoli, Stefano [1 ]
Ricci, Maurizio [1 ]
机构：
[1] Univ Perugia, Dept Pharmaceut Sci, I-06123 Perugia, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 03期
关键词：
RNA lipid nanoparticles; RNA delivery systems; biodrug nanotechnology; TECHNOLOGIES; THERAPEUTICS; VACCINES; MEDICINE;
D O I：
10.3390/ijms24032218
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
As an appealing alternative to treat and prevent diseases ranging from cancer to COVID-19, mRNA has demonstrated significant clinical effects. Nanotechnology facilitates the successful implementation of the systemic delivery of mRNA for safe human consumption. In this manuscript, we provide an overview of current mRNA therapeutic applications and discuss key biological barriers to delivery and recent advances in the development of nonviral systems. The relevant challenges that LNPs face in achieving cost-effective and widespread clinical implementation when delivering mRNA are likewise discussed.
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页数：11
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