Safety and efficacy of SARS-CoV-2 vaccination in patients with immune thrombocytopenia: A two-centre review

被引：2
|
作者：
Stefani, Sara [1 ,2 ]
Buti, Noora [1 ]
Hart, Alice C. J. [1 ,2 ]
Paul, Deena [1 ]
Rizvi, Naghma [1 ]
Ragoonanan, Vashti [1 ]
Vladescu, Camelia [1 ]
Szydlo, Richard [2 ]
Ademokun, Christine [1 ]
Jansen, A. J. Gerard [3 ]
Cooper, Nichola [1 ,2 ]
机构：
[1] Imperial Coll Healthcare NHS Trust, London, England
[2] Imperial Coll London, Ctr Haematol, Dept Immunol & Inflammat, London, England
[3] Univ Med Ctr Rotterdam, Erasmus MC, Dept Haematol, Rotterdam, Netherlands
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2024年 / 204卷 / 01期
关键词：
antibodies; COVID-19; ITP; vaccines; COVID-19; VACCINATION;
D O I：
10.1111/bjh.19212
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Multiple studies have reported immune thrombocytopenia (ITP) relapse following SARS-CoV-2 vaccination, however baseline ITP relapse rate and antibody response to vaccination are not known. Patients with ITP who received at least one of the first three SARS-CoV-2 vaccination doses were included in the study. One hundred and twenty-four patients met the inclusion criteria. Relapse rate was 4.2% following a first vaccine dose, 9.1% after a second and 2.9% after a third; baseline relapse rate was 7.6%. Ninety-four per cent of patients who received three vaccine doses developed a clinical antibody response. SARS-CoV-2 vaccination appears to be safe and effective in patients with ITP.
引用
收藏
页码：324 / 328
页数：5
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