Contributions of NR1H3 genetic polymorphisms to susceptibility and effects of narrowband UVB phototherapy to nonsegmental vitiligo

被引:0
|
作者
Xu, Meifeng [1 ]
Xu, Qiuyu [2 ]
Liu, Yan [1 ]
Li, Xiaoli [1 ]
Wang, Mei [1 ]
Dong, Wei [3 ]
Song, Yuning [4 ]
Xiao, Shengxiang [1 ]
机构
[1] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Dermatol, 157 Xiwu Rd, Xian 710004, Shaanxi, Peoples R China
[2] Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Med & Forens, Xian, Shaanxi, Peoples R China
[3] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Lab Med, Xian, Shaanxi, Peoples R China
[4] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Xian, Shaanxi, Peoples R China
关键词
RECEPTOR EXPRESSION; PATHOGENESIS;
D O I
10.1038/s41598-023-30047-7
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Vitiligo is the most common depigmenting disorder to which both genetic and environmental factors contribute. The aim of the current work was to evaluate the relationship between polymorphisms of the gene nuclear receptor subfamily 1 Group H member 3 (NR1H3) and the risk of vitiligo and phototherapy effects in the Chinese Han population. Two independent samples were enrolled to form the discovery set (comprised of 1668 nonsegmental vitiligo [NSV] patients and 2542 controls) and the validation set (comprised of 745 NSV patients and 1492 controls). A total of 13 tag single nucleotide polymorphisms (SNPs) were genotyped in the samples from the discovery stage. SNPs that achieved nominal significance were validated in another independent sample set. The serum level of NR1H3 protein was assayed using enzyme-linked immunosorbent assay kits in the validation set. Genetic association analysis was carried out at allelic and genotypic levels. The therapeutic effects of significant SNPs were examined in the validation set. The SNP rs3758672 was significantly associated with NSV. The A allele was correlated with NSV risk and poorer therapeutic effects. The A allele was strongly correlated with the increased level of serum NR1H3 in both controls and patients. In summary, SNP rs3758672 in NR1H3 was significantly associated with both disease susceptibility and individualized therapeutic effects of NSV in study participants with Han Chinese ancestry.
引用
收藏
页数:9
相关论文
共 9 条
  • [1] Contributions of NR1H3 genetic polymorphisms to susceptibility and effects of narrowband UVB phototherapy to nonsegmental vitiligo
    Meifeng Xu
    Qiuyu Xu
    Yan Liu
    Xiaoli Li
    Mei Wang
    Wei Dong
    Yuning Song
    Shengxiang Xiao
    Scientific Reports, 13
  • [2] Effects of NR1H3 Genetic Variation on the Expression of Liver X Receptor α and the Progression of Alzheimer's Disease
    Natunen, Teemu
    Martiskainen, Henna
    Sarajarvi, Timo
    Helisalmi, Seppo
    Pursiheimo, Juha-Pekka
    Viswanathan, Jayashree
    Laitinen, Marjo
    Makinen, Petra
    Kauppinen, Tarja
    Rauramaa, Tuomas
    Leinonen, Ville
    Alafuzoff, Irina
    Haapasalo, Annakaisa
    Soininen, Hilkka
    Hiltunen, Mikko
    PLOS ONE, 2013, 8 (11):
  • [3] Genetic variants regulate NR1H3 expression and contribute to multiple sclerosis risk
    Zhang, Yan
    Wang, Longcai
    Jia, Haiyang
    Liao, Mingzhi
    Chen, Xiaoyun
    Xu, Jianyong
    Bao, Yunjuan
    Liu, Guiyou
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2018, 390 : 162 - 165
  • [4] NR1H3 (LXR alpha) Gene Polymorphisms Are Associated with Systemic Lupus Erythematosus in Koreans.
    Jeon, Ja-Young
    Kim, Hyoun-Ah
    Suh, Chang-Hee
    ARTHRITIS AND RHEUMATISM, 2012, 64 (10): : S962 - S963
  • [5] Functional Effect Of NR1H3 (LXRA) Promoter Polymorphisms In Korean Patients With Systemic Lupus Erythematosus.
    Jeon, Ja-Young
    Kim, Hyoun-Ah
    Jung, Ju-Yang
    Suh, Chang-Hee
    ARTHRITIS AND RHEUMATISM, 2013, 65 : S691 - S691
  • [6] Liver X receptors alpha gene (NR1H3) promoter polymorphisms are associated with systemic lupus erythematosus in Koreans
    Ja-Young Jeon
    Jin-Young Nam
    Hyoun-Ah Kim
    Yong-Beom Park
    Sang-Cheol Bae
    Chang-Hee Suh
    Arthritis Research & Therapy, 16
  • [7] Liver X receptors alpha gene (NR1H3) promoter polymorphisms are associated with systemic lupus erythematosus in Koreans
    Jeon, Ja-Young
    Nam, Jin-Young
    Kim, Hyoun-Ah
    Park, Yong-Beom
    Bae, Sang-Cheol
    Suh, Chang-Hee
    ARTHRITIS RESEARCH & THERAPY, 2014, 16 (03)
  • [8] Roles of NR1I3 and NR1H4 polymorphisms in the susceptibility to antituberculosis drug-induced liver injury in China: a case-control study
    Xu, Xiaoyan
    Chen, Ruina
    Lu, Lihuan
    Cheng, Jingru
    He, Xiaomin
    Pan, Hongqiu
    Zhang, Meiling
    Yi, Honggang
    Tang, Shaowen
    FRONTIERS IN GENETICS, 2024, 15
  • [9] Effects of genetic polymorphisms of MDR1, FMO3 and CYP1A2 on susceptibility to colorectal cancer in Koreans
    Bae, Sun-Young
    Choi, Sun-Keun
    Kim, Kyung-Rae
    Park, Chang-Shin
    Lee, Sung-Keun
    Roh, Hyung-Keun
    Shin, Dong-Woon
    Pie, Jae-Eun
    Woo, Ze-Hong
    Kang, Ju-Hee
    CANCER SCIENCE, 2006, 97 (08) : 774 - 779