Senescence of bone marrow fat cells: A new clue for glucocorticoid-induced bone deterioration

被引：8
|
作者：
Tong, Liping [1 ]
Chen, Di [1 ,2 ]
机构：
[1] Chinese Acad Sci, Shenzhen Inst Adv Technol, Res Ctr Comp Aided Drug Discovery, Shenzhen 518055, Peoples R China
[2] Shenzhen Inst Adv Technol, Fac Pharmaceut Sci, Shenzhen 518055, Peoples R China
来源：
CELL METABOLISM | 2023年 / 35卷 / 04期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/j.cmet.2023.03.009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Glucocorticoid (GC)-induced osteoporosis is the most common secondary cause of osteoporosis, resulting in fractures and significant morbidity. In this issue of Cell Metabolism, Liu et al. reveal that in response to GCs, bone marrow adipocytes (BMAds) undergo rapid cellular senescence, triggering secondary senescence in bone marrow and causing bone deterioration.
引用
收藏
页码：551 / 553
页数：3
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