Synthesis of a-Hydroxyl and a-Amino Pyridinyl Esters via Photoreductive Dual Radical Cross-Coupling

被引：4

作者：

Cui, Xian-Chao ^{[1
]}

Zhang, Hu ^{[1
]}

Zhang, Hao ^{[1
]}

Wang, Yi-Ping ^{[1
]}

Qu, Jian-Ping ^{[2
]}

Kang, Yan-Biao ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

[2] Nanjing Tech Univ, Inst Adv Synth, Sch Chem & Mol Engn, Nanjing 211816, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 39期

基金：

中国国家自然科学基金;

关键词：

6-STEP SYNTHESIS; CATALYSIS; ACCESS;

D O I：

10.1021/acs.orglett.3c02780

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method for the synthesis of a-hydroxyl and a-amino pyridinyl esters via photoreductive dual radical cross-coupling catalyzed by the super-organoreductant CBZ6 has been developed. A wide range of 2-pyridinylation and 4-pyridinylation of either a-ketoesters or imine derivatives has been achieved. The applications in the synthesis of pyridinyl amino-hydroxyl acids as well as a new chiral oxazoline ligand have also been accomplished.

引用

页码：7198 / 7203

页数：6

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