Synaptotagmin is not only a calcium sensor, but also exerts entropic forces that drive membrane fusion

被引：0
|
作者：
Butu, Ioana C. [1 ]
An, Dong [1 ]
McDargh, Zachary A. [1 ]
O'Shaughnessy, Ben [1 ]
机构：
[1] Columbia Univ, Chem Engn, New York, NY USA
来源：
BIOPHYSICAL JOURNAL | 2023年 / 122卷 / 03期
关键词：
D O I：
暂无
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
2241-Plat
引用
收藏
页码：461A / 461A
页数：1
相关论文
共 22 条
  • [1] Entropic forces drive self-organization and membrane fusion by SNARE proteins
    Mostafavi, Hakhamanesh
    Thiyagarajan, Sathish
    Stratton, Benjamin S.
    Karatekin, Erdem
    Warner, Jason M.
    Rothman, James E.
    O'Shaughnessy, Ben
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (21) : 5455 - 5460
  • [2] Simulations on physiological timescales show SNAREs drive membrane fusion by entropic forces
    An, Dong
    Zeng, Jin
    McDargh, Zachary A.
    Ben O'Shaughnessy
    Su, Rui
    BIOPHYSICAL JOURNAL, 2023, 122 (03) : 499A - 499A
  • [3] Entropic Forces, Zippering Pressure and Membrane Thinning Drive Snare-Mediated Membrane Fusion
    Zeng, Jin
    McDargh, Zachary A.
    O'Shaughnessy, Ben
    BIOPHYSICAL JOURNAL, 2021, 120 (03) : 51A - 51A
  • [4] Role of the lysosomal calcium sensor synaptotagmin VII in membrane traffic and phagocytosis
    Andrews, N. W.
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2011, 41 : 33 - 33
  • [5] Calcium-independent stimulation of membrane fusion and SNAREpin formation by synaptotagmin I
    Mahal, LK
    Sequeira, SM
    Gureasko, JM
    Söllner, TH
    JOURNAL OF CELL BIOLOGY, 2002, 158 (02): : 273 - 282
  • [6] Membrane Penetration by Synaptotagmin Is Required for Coupling Calcium Binding to Vesicle Fusion In Vivo
    Paddock, Brie E.
    Wang, Zhao
    Biela, Laurie M.
    Chen, Kaiyun
    Getzy, Michael D.
    Striegel, Amelia
    Richmond, Janet E.
    Chapman, Edwin R.
    Featherstone, David E.
    Reist, Noreen E.
    JOURNAL OF NEUROSCIENCE, 2011, 31 (06): : 2248 - 2257
  • [7] Synaptotagmin-1 Utilizes Membrane Bending and SNARE Binding to Drive Fusion Pore Expansion
    Lynch, Kara L.
    Gerona, Roy R. L.
    Kielar, Dana M.
    Martens, Sascha
    McMahon, Harvey T.
    Martin, Thomas F. J.
    MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (12) : 5093 - 5103
  • [8] SNARE-mediated membrane fusion is a two-stage process driven by entropic forces
    McDargh, Zachary A.
    Polley, Anirban
    O'Shaughnessy, Ben
    FEBS LETTERS, 2018, 592 (21): : 3504 - 3515
  • [9] SNARE-mediated membrane fusion is slower for larger vesicles because entropic forces are weaker
    Butu, Ioana C.
    An, Dong
    O'Shaughnessy, Ben
    BIOPHYSICAL JOURNAL, 2024, 123 (03) : 238A - 238A
  • [10] Snare-Mediated Membrane Fusion is a Two-Stage Process Driven by Entropic Forces
    McDargh, Zachary A.
    Polley, Anirban
    O'Shaughnessy, Ben
    BIOPHYSICAL JOURNAL, 2019, 116 (03) : 314A - 314A
123