Metabolomic and Proteomic Profiling of Athletes Performing Physical Activity under Hypoxic Conditions

被引：3
|
作者：
Malsagova, Kristina A. [1 ]
Kopylov, Arthur T. [1 ]
Stepanov, Alexander A. [1 ]
Kulikova, Liudmila I. [1 ,2 ]
Izotov, Alexander A. [1 ]
Yurku, Ksenia A. [3 ]
Balakin, Evgenii I. [3 ]
Pustovoyt, Vasiliy I. [3 ]
Kaysheva, Anna L. [1 ]
机构：
[1] Inst Biomed Chem, Moscow 119121, Russia
[2] Russian Acad Sci, Inst Math Problems Biol RAS Branch, Keldysh Inst Appl Math, Pushchino 142290, Russia
[3] Fed Med Biol Agcy, State Res Ctr, Burnasyan Fed Med Biophys Ctr, Moscow 119435, Russia
来源：
SPORTS | 2024年 / 12卷 / 03期
关键词：
metabolome; proteome; molecular profile; athletes; mass spectrometry analysis; CREATINE-KINASE; SOCCER MATCH; ENDURANCE EXERCISE; IMMUNE-SYSTEM; HAPTOGLOBIN; BIOMARKERS; RESPONSES; MARKERS; SPORTS; SUPPLEMENTATION;
D O I：
10.3390/sports12030072
中图分类号：
G8 [体育];
学科分类号：
04 ; 0403 ;
摘要：
Proteomic and metabolomic research enables quantitation of the molecular profile of athletes. Multiomic profiling was conducted using plasma samples collected from 18 male athletes performing aerobic activity (running) at high altitude. Metabolomic profiling detected changes in the levels of 4-hydroxyproline, methionine, oxaloacetate, and tyrosine during the recovery period. Furthermore, proteomic profiling revealed changes in expression of proteins contributing to the function of the immune system, muscle damage, metabolic fitness and performance, as well as hemostasis. Further research should focus on developing metabolic models to monitor training intensity and athlete adaptation.
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页数：29
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