IDO1/COX2 Expression Is Associated with Poor Prognosis in Colorectal Cancer Liver Oligometastases

被引:3
|
作者
Wu, Miaoqing [1 ,2 ]
Wu, Xiaoliang [3 ]
Wang, Xing [4 ]
Hong, Xiangchan [3 ]
Liu, Yifan [1 ,2 ]
Lv, Guangzhao [1 ,2 ]
Li, Cong [1 ,2 ,5 ]
Pan, Zhizhong [1 ,2 ,5 ]
Zhang, Rongxin [1 ,2 ,5 ]
Chen, Gong [1 ,2 ,5 ]
机构
[1] Sun Yat sen Univ, Canc Ctr, Dept Colorectal Surg, Guangzhou 510060, Peoples R China
[2] Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou 510060, Peoples R China
[3] Southern Med Univ, Shenzhen Hosp, Dept Oncol, Shenzhen 518000, Peoples R China
[4] Jiangxi Med Coll, Affiliated Hosp 1, Nanchang 330000, Peoples R China
[5] Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Peoples R China
来源
JOURNAL OF PERSONALIZED MEDICINE | 2023年 / 13卷 / 03期
基金
中国国家自然科学基金;
关键词
colorectal cancer; oligometastases; IDO1; COX2; prognosis; INDOLEAMINE 2,3-DIOXYGENASE; RADIOFREQUENCY ABLATION; CELL INFILTRATION; IDO1;
D O I
10.3390/jpm13030496
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Background: IDO1 and COX2 have emerged as promising immunotherapy targets. It is unclear whether IDO1 and COX2 expression levels in colorectal cancer (CRC) patients with liver oligometastases could be independent predictors of overall survival (OS) and progression-free survival (PFS). The purpose of this study was to investigate the correlation of IDO1 and COX2 expression levels with OS and PFS in CRC patients with liver oligometastases. Methods: The expression levels of IDO1 and COX2 were assessed by immunohistochemistry in 107 specimens from patients with liver oligometastases. The correlation between the expression of IDO1 and COX2 and the clinicopathological parameters and OS/PFS in patients was examined. Results: The expression level of IDO1/COX2 was significantly correlated with age and was not associated with gender, BMI, T stage, N stage, primary tumor size, liver metastasis size, CEA, CA19-9, CD3 TILs or CD8 TILs. In univariate analysis, we found that IDO1/COX2 expression, CEA and N stage all yielded significantly poor OS and PFS outcomes. In our multivariate Cox model, IDO1/COX2 coexpression, CEA and N stage were found to be significantly correlated with OS; IDO1/COX2 coexpression and CEA were significantly correlated with PFS. Conclusions: IDO1/COX2 coexpression plays a pivotal role and may act as a potential prognostic biomarker for survival in CRC patients with liver oligometastases.
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页数:10
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