Vaccine Effectiveness Against Influenza A-Associated Hospitalization, Organ Failure, and Death: United States, 2022-2023

被引：16

作者：

Lewis, Nathaniel M. ^{[1
]}

Zhu, Yuwei ^{[2
]}

Peltan, Ithan D. ^{[3
,4
]}

Gaglani, Manjusha ^{[5
,6
,7
]}

McNeal, Tresa ^{[5
,8
]}

Ghamande, Shekhar ^{[9
]}

Steingrub, Jay S. ^{[10
]}

Shapiro, Nathan, I ^{[11
]}

Duggal, Abhijit ^{[12
]}

Bender, William S. ^{[13
]}

Taghizadeh, Leyla ^{[14
]}

Brown, Samuel M.

Hager, David N. ^{[15
]}

Gong, Michelle N. ^{[16
]}

Mohamed, Amira ^{[17
]}

Exline, Matthew C. ^{[17
]}

Khan, Akram ^{[18
]}

Wilson, Jennifer G. ^{[19
]}

Qadir, Nida ^{[20
]}

Chang, Steven Y. ^{[20
]}

Ginde, Adit A. ^{[21
]}

Mohr, Nicholas M. ^{[22
]}

Mallow, Christopher ^{[23
]}

Lauring, Adam S. ^{[24
,25
]}

Johnson, Nicholas J. ^{[26
,27
]}

Gibbs, Kevin W. ^{[28
]}

Kwon, Jennie H. ^{[29
]}

Columbus, Cristie ^{[6
]}

Gottlieb, Robert L. ^{[30
]}

Raver, Catherine ^{[6
]}

Vaughn, Ivana A. ^{[31
]}

Ramesh, Mayur ^{[32
]}

Johnson, Cassandra ^{[2
]}

Lamerato, Lois ^{[33
]}

Safdar, Basmah ^{[34
]}

Casey, Jonathan D. ^{[35
]}

Rice, Todd W. ^{[35
]}

Halasa, Natasha ^{[36
]}

Chappell, James D. ^{[36
]}

Grijalva, Carlos G. ^{[37
]}

Talbot, H. Keipp ^{[35
,37
]}

Baughman, Adrienne ^{[38
]}

Womack, Kelsey N. ^{[39
]}

Swan, Sydney A. ^{[2
]}

Harker, Elizabeth ^{[1
]}

Price, Ashley ^{[1
]}

Decuir, Jennifer ^{[1
]}

Surie, Diya ^{[1
]}

Ellington, Sascha ^{[1
]}

Self, Wesley H. ^{[40
,41
]}

机构：

[1] Ctr Dis Control & Prevent CDC, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA

[2] Vanderbilt Univ, Med Ctr, Dept Biostat, Nashville, TN USA

[3] Intermt Med Ctr, Dept Med, Murray, UT USA

[4] Univ Utah, Salt Lake City, UT USA

[5] Baylor Scott & White Hlth, Temple, TX USA

[6] Baylor Scott & White Hlth, Dallas, TX USA

[7] Texas A&M Univ, Coll Med, Temple, TX USA

[8] Baylor Coll Med, Temple, TX USA

[9] Texas A&M Univ, Coll Med, Baylor Scott & White Hlth, Temple, TX USA

[10] Baystate Med Ctr, Dept Med, Springfield, MA USA

[11] Beth Israel Deaconess Med Ctr, Dept Emergency Med, Boston, MA USA

[12] Cleveland Clin, Dept Med, Cleveland, OH USA

[13] Emory Univ, Dept Med, Atlanta, GA USA

[14] Hennepin Cty Med Ctr, Dept Emergency Med, Minneapolis, MN USA

[15] Johns Hopkins Univ, Dept Med, Sch Med, Baltimore, MD USA

[16] Albert Einstein Coll Med, Montefiore Med Ctr, Dept Med, Bronx, NY USA

[17] Ohio State Univ, Dept Med, Columbus, OH USA

[18] Oregon Hlth & Sci Univ, Dept Med, Portland, OR USA

[19] Stanford Univ, Sch Med, Dept Emergency Med, Stanford, CA USA

[20] Univ Calif Los Angeles, Dept Med, Los Angeles, CA USA

[21] Univ Colorado, Sch Med, Dept Emergency Med, Aurora, CO USA

[22] Univ Iowa, Carver Coll Med, Iowa City, IA USA

[23] Univ Miami, Dept Med, Miami, FL USA

[24] Univ Michigan, Dept Internal Med, Ann Arbor, MI USA

[25] Univ Michigan, Dept Microbiol & Immunol, Ann Arbor, MI USA

[26] Univ Washington, Dept Emergency Med, Seattle, WA USA

[27] Univ Washington, Div Pulm Crit Care & Sleep Med, Seattle, WA USA

[28] Wake Forest Sch Med, Dept Med, Winston Salem, NC USA

[29] Washington Univ, Dept Med, St Louis, MO USA

[30] Baylor Univ, Baylor Scott & White Heart & Vasc Hosp, Baylor Scott & White Res Inst, Med Ctr Dallas, Dallas, TX USA

[31] Henry Ford Hlth, Dept Publ Hlth Sci, Detroit, MI USA

[32] Henry Ford Hlth, Div Infect Dis, Detroit, MI USA

[33] Henry Ford Hlth, Dept Publ Hlth Sci, Detroit, MI USA

[34] Yale Univ, Sch Med, Emergency Med, New Haven, CT USA

[35] Vanderbilt Univ, Dept Med, Med Ctr, Nashville, TN USA

[36] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN USA

[37] Vanderbilt Univ, Med Ctr, Dept Hlth Policy, Nashville, TN USA

[38] Vanderbilt Univ, Med Ctr, Dept Emergency Med, Nashville, TN USA

[39] Vanderbilt Univ, Vanderbilt Inst Clin & Translat Res, Med Ctr, Nashville, TN USA

[40] Vanderbilt Inst Clin & Translat Res, Dept Emergency Med, Nashville, TN USA

[41] Vanderbilt Univ, Med Ctr, Nashville, TN USA

来源：

CLINICAL INFECTIOUS DISEASES | 2024年 / 78卷 / 04期

基金：

美国医疗保健研究与质量局; 美国国家卫生研究院;

关键词：

influenza; vaccine effectiveness; attenuation; organ failure; acute respiratory illness; TEST-NEGATIVE DESIGN; NETWORK; ADULTS;

D O I：

10.1093/cid/ciad677

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background Influenza circulation during the 2022-2023 season in the United States largely returned to pre-coronavirus disease 2019 (COVID-19)-pandemic patterns and levels. Influenza A(H3N2) viruses were detected most frequently this season, predominately clade 3C.2a1b.2a, a close antigenic match to the vaccine strain.Methods To understand effectiveness of the 2022-2023 influenza vaccine against influenza-associated hospitalization, organ failure, and death, a multicenter sentinel surveillance network in the United States prospectively enrolled adults hospitalized with acute respiratory illness between 1 October 2022, and 28 February 2023. Using the test-negative design, vaccine effectiveness (VE) estimates against influenza-associated hospitalization, organ failures, and death were measured by comparing the odds of current-season influenza vaccination in influenza-positive case-patients and influenza-negative, SARS-CoV-2-negative control-patients.Results A total of 3707 patients, including 714 influenza cases (33% vaccinated) and 2993 influenza- and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-negative controls (49% vaccinated) were analyzed. VE against influenza-associated hospitalization was 37% (95% confidence interval [CI]: 27%-46%) and varied by age (18-64 years: 47% [30%-60%]; >= 65 years: 28% [10%-43%]), and virus (A[H3N2]: 29% [6%-46%], A[H1N1]: 47% [23%-64%]). VE against more severe influenza-associated outcomes included: 41% (29%-50%) against influenza with hypoxemia treated with supplemental oxygen; 65% (56%-72%) against influenza with respiratory, cardiovascular, or renal failure treated with organ support; and 66% (40%-81%) against influenza with respiratory failure treated with invasive mechanical ventilation.Conclusions During an early 2022-2023 influenza season with a well-matched influenza vaccine, vaccination was associated with reduced risk of influenza-associated hospitalization and organ failure. During an early 2022-2023 influenza season with well-matched influenza vaccine, substantial vaccine effectiveness was observed against influenza-associated hospitalization and a range of severe influenza-associated outcomes, including organ failure, intensive care unit (ICU) admission, and need for invasive mechanical ventilation.

引用

页码：1056 / 1064

页数：9

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