Role of cellular metabolism in the control of chronic viral hepatitis

被引：0
|
作者：
Diaz, Olivier [1 ]
Legrand, Anne-Flore [1 ]
El-Orch, Walid [1 ]
Jacolin, Florentine [1 ]
Lotteau, Vincent [1 ]
Ramiere, Christophe [1 ,2 ]
Vidalain, Pierre-Olivier [1 ]
Perrin-Cocon, Laure [1 ]
机构：
[1] Univ Lyon, Univ Claude Bernard Lyon 1, Inserm U1111, Ecole Normale Super ENS Lyon,Ctr Int Rech Infectio, F-69007 Lyon, France
[2] Hop Croix Rousse, Serv Virol, Hosp Civils Lyon, Lyon, France
来源：
M S-MEDECINE SCIENCES | 2023年 / 39卷 / 10期
关键词：
C VIRUS-INFECTION; MYCOPHENOLIC-ACID; HEPATOCELLULAR-CARCINOMA; X PROTEIN; HBV; REPLICATION; EXPRESSION; PATHWAYS; IMMUNITY; GENES;
D O I：
10.1051/medsci/2023125
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Hepatitis viruses modify the cellular metabolism of hepatocytes by interacting with specific enzymes such as glucokinase. The metabolic changes induced by viruses can have a direct impact on the innate antiviral response. The complex interactions between viral components, innate immunity, and hepatocyte metabolism explain why chronic hepatitis infections lead to liver inflammation, progressing to cirrhosis, fibrosis, and hepatocellular carcinoma. Metabolic regulators could be used in innovative therapies to deprive viruses of key metabolites and induce an antiviral defense.
引用
收藏
页码：754 / 762
页数：9
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