Therapeutic Drug Monitoring and Population Pharmacokinetic Analysis of Teicoplanin among Chinese Patients with Gram-Positive Infections in a Tertiary Hospital

被引:0
|
作者
Li, Yuan-Yuan [1 ,2 ]
Zhang, Guan-Xuan-Zi [1 ,2 ]
Wang, Jin [1 ]
Bai, Nan [1 ]
Cai, Yun [1 ]
机构
[1] Peoples Liberat Army Gen Hosp, Med Supplies Ctr, Ctr Med Clin Res, Dept Pharm, Beijing, Peoples R China
[2] PLA Med Sch, Beijing, Peoples R China
关键词
GUIDELINES; EFFICACY; SAFETY;
D O I
10.1155/2023/2681979
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Background. To explore the use of teicoplanin among Chinese patients with Gram-positive infections in a tertiary hospital. Methods. The medical records of patients, who were monitored for teicoplanin plasma concentration (TPC) from December 2017 to February 2019, were collected. By combining the therapeutic drug monitoring (TDM) and nonlinear mixed-effects model, a population pharmacokinetic (PPK) model of teicoplanin was established. Results. The proportions of TPCs lower and higher than 10 mg/L were nearly the same (102 vs. 108 cases). A two-compartment model of teicoplanin PPK in Chinese patients was established. Compared with 400 mg, the 600 mg regimen was more able to reach the target concentration (10 mg/L), especially for high-weight patients. Conclusions. The standard regimen of teicoplanin, 400 mg, failed to reach the target value in the present population. Moreover, the 600 mg regimen was feasible for high-weight patients based on TDM and individualized pharmacokinetic dosing adjustment.
引用
收藏
页数:11
相关论文
共 50 条
  • [1] Teicoplanin Therapeutic Drug Monitoring and Treatment Outcomes in Children With Gram-Positive Infections
    Loane, Georgia
    Gwee, Amanda
    JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY, 2021, 10 (05) : 682 - 685
  • [2] TEICOPLANIN FOR THERAPY OF GRAM-POSITIVE INFECTIONS IN NEUTROPENIC PATIENTS
    VERHAGEN, C
    DEPAUW, BE
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY RESEARCH, 1987, 7 (06) : 491 - 498
  • [3] Population pharmacokinetic analysis of vancomycin in patients with gram-positive infections and the influence of infectious disease type
    Yamamoto, M.
    Kuzuya, T.
    Baba, H.
    Yamada, K.
    Nabeshima, T.
    JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2009, 34 (04) : 473 - 483
  • [4] Vancomycin vs teicoplanin in the treatment of Gram-positive infections: a pharmacoeconomic analysis in a Turkish University Hospital
    Sancar, Aylin Acar
    Yegenoglu, Selen
    de Vries, Robin
    Postma, Maarten J.
    Simsek, Nimet
    Pechlivanoglou, Petros
    Unal, Serhat
    PHARMACY WORLD & SCIENCE, 2008, 30 (06): : 916 - 923
  • [5] Vancomycin vs teicoplanin in the treatment of Gram-positive infections: a pharmacoeconomic analysis in a Turkish University Hospital
    Aylin Acar Sancar
    Selen Yegenoglu
    Robin de Vries
    Maarten J. Postma
    Nimet Simsek
    Petros Pechlivanoglou
    Serhat Unal
    Pharmacy World & Science, 2008, 30
  • [6] TEICOPLANIN IN GRAM-POSITIVE INFECTIONS - MULTICENTER OPEN STUDY IN EASTERN FRANCE IN 66 GRAM-POSITIVE INFECTED PATIENTS
    DUREUX, JB
    CANTON, P
    CHAVANET, P
    CHIPPAUX, C
    DUPEYRON, JP
    ESTAVOYER, JM
    GIORGI, C
    JAEGER, A
    JEHL, F
    KAZMIERZACK, A
    LUTIN, P
    MAY, T
    MONTEIL, H
    PETTER, JD
    PORTIER, H
    RIO, Y
    REMY, G
    TALON, D
    TEMPE, JD
    VEDEL, M
    WEBER, M
    TARRAL, A
    PATHOLOGIE BIOLOGIE, 1987, 35 (05): : 511 - 515
  • [7] Population Pharmacokinetics and Pharmacodynamics of Teicoplanin and C-Reactive Protein in Hospitalized Patients With Gram-Positive Infections
    Ogami, Chika
    Tsuji, Yasuhiro
    Muraki, Yuichi
    Mizoguchi, Akiko
    Okuda, Masahiro
    To, Hideto
    CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2020, 9 (02): : 175 - 188
  • [8] A retrospective analysis to estimate trough concentrations of teicoplanin in patients with suspected or documented Gram-positive infections
    Luo, Yi-Fan
    Wang, Yi-Dan
    Ren, Li-Xiang
    Yang, Chu
    BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 59
  • [9] Retrospective analysis of relationships among the dose regimen, trough concentration, efficacy, and safety of teicoplanin in Chinese patients with moderate-severe Gram-positive infections
    Zhou, Lijuan
    Gao, Yanqiu
    Cao, Wei
    Liu, Jia
    Guan, Hongya
    Zhang, Hua
    Shi, Yun
    Lv, Wenying
    Cheng, Long
    INFECTION AND DRUG RESISTANCE, 2018, 11 : 29 - 36
  • [10] Pharmacokinetic and pharmacodynamic profile of linezolid in healthy volunteers and patients with Gram-positive infections
    MacGowan, AP
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 51 : 17 - 25