Thiazides in chronic kidney disease: "back to the future"

被引：4

作者：

de la Espriella, Rafael ^{[1
]}

Cobo, Marta ^{[2
]}

Nunez, Julio ^{[1
,3
,4
]}

机构：

[1] Univ Valencia, Hosp Clin, Dept Cardiol, Valencia, Spain

[2] Hosp Univ Puerta Hierro Majadahonda, Dept Cardiol, Madrid, Spain

[3] Centro Invest Biomed Red Enfermedades Cardiov, Madrid, Spain

[4] Univ Valencia, Dept Med, Valencia, Spain

来源：

CLINICAL KIDNEY JOURNAL | 2023年 / 16卷 / 01期

关键词：

chronic renal insufficiency; diuretics; heart failure; hypertension; thiazides; CHLORTHALIDONE;

D O I：

10.1093/ckj/sfac228

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The thiazide class diuretics are first-line agents for managing hypertension either as monotherapy or as a fixed-dose combination with other antihypertensive drugs. However, despite the extensive experience with these drugs for >60 years, there is general reluctance to use these agents in patients with advanced chronic kidney disease (CKD) because of concerns about their efficacy and safety as kidney function declines. In this issue of Clinical Kidney Journal, Minutolo et al. performed an updated review of the pharmacological properties, efficacy and side effects and randomized controlled trials that tested these drugs in patients with CKD.

引用

页码：1 / 4

页数：4

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