How Much Does Thrombocytopenia Affect the Predictive Risk of Mortality Score (Prism III) in Critically-ill Children?

Background: The main goal of the pediatric intensive care unit (PICU) is to reduce mortality. PRISM is one of the predictor models of mortality in patients admitted to the PICU. This study aimed to evaluate the effect of thrombocytopenia on the predicted death rate (PDR) in pediatrics admitted to the PICU, by the PRISM scoring system. Methods: This cross-sectional study was performed on patients admitted to the PICU of Akbar Hospital, Mashhad, Iran, from March 2019 to March 2020. Based on the information collected during the first 4 h of patient admission to the PICU, the PRISM score was calculated by the PRISM online calculator. The percentage of PDR calculated for each patient indicated the possibility of patient mortality. Statistical analysis was carried out using SPSS software (Version 25, SPSS Inc., Chicago, IL, USA) at the significant level of alpha=0.05. Results: The results of data analysis showed that with the increase in the severity of thrombocytopenia, the mortality percentage increased and corresponded with the rate of PDR. Conclusions: Based on these results, it can be concluded that the effect of thrombocytopenia on mortality corresponded with what was considered in the PRISM scoring system and thrombocytopenia does not increase the risk of mortality.