Neuroimaging genomics as a window into the evolution of human sulcal organization

被引:0
|
作者
Goltermann, Ole [1 ,2 ,3 ]
Alagoz, Gokberk
Molz, Barbara [2 ]
Fisher, Simon E. [2 ,4 ,5 ]
机构
[1] Max Planck Sch Cognit, Stephanstr 1a, D-04103 Leipzig, Germany
[2] Max Planck Inst Psycholinguist, Language & Genet Dept, Wundtlaan 1, NL-6525 XD Nijmegen, Netherlands
[3] Univ Med Ctr Hamburg Eppendorf, Inst Syst Neurosci, Martinistr 52, D-20246 Hamburg, Germany
[4] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Thomas Aquinostraat 4, NL-6525 GD Nijmegen, Netherlands
[5] Max Planck Inst Psycholinguist, Language & Genet Dept, Wundtlaan 1, NL-6525 XD Nijmegen, Netherlands
关键词
evolution; genetics; neuroimaging; sulcus; COVERAGE NEANDERTHAL GENOME; WIDE ASSOCIATION; HERITABILITY; MORPHOLOGY; LANGUAGE; SPOKEN; DEPTH; HAND;
D O I
10.1093/cercor/bhae078
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Primate brain evolution has involved prominent expansions of the cerebral cortex, with largest effects observed in the human lineage. Such expansions were accompanied by fine-grained anatomical alterations, including increased cortical folding. However, the molecular bases of evolutionary alterations in human sulcal organization are not yet well understood. Here, we integrated data from recently completed large-scale neuroimaging genetic analyses with annotations of the human genome relevant to various periods and events in our evolutionary history. These analyses identified single-nucleotide polymorphism (SNP) heritability enrichments in fetal brain human-gained enhancer (HGE) elements for a number of sulcal structures, including the central sulcus, which is implicated in human hand dexterity. We zeroed in on a genomic region that harbors DNA variants associated with left central sulcus shape, an HGE element, and genetic loci involved in neurogenesis including ZIC4, to illustrate the value of this approach for probing the complex factors contributing to human sulcal evolution.
引用
收藏
页数:11
相关论文
共 50 条
  • [1] Using neuroimaging genomics to investigate the evolution of human brain structure
    Alagoz, Gokberk
    Molz, Barbara
    Eising, Else
    Schijven, Dick
    Francks, Clyde
    Stein, Jason L.
    Fisher, Simon E.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 119 (40)
  • [2] INTEGRATING MOLECULAR ANTHROPOLOGY AND NEUROIMAGING GENOMICS TO SHED NEW LIGHT ON HUMAN BRAIN EVOLUTION
    Fisher, Simon
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2019, 29 : S771 - S771
  • [3] Tunicate genomics: a window into chordate development and evolution
    Zeller, R. W.
    INTEGRATIVE AND COMPARATIVE BIOLOGY, 2010, 50 : E196 - E196
  • [4] Sulcal organization in the medial frontal cortex provides insights into primate brain evolution
    Amiez, Celine
    Sallet, Jerome
    Hopkins, William D.
    Meguerditchian, Adrien
    Hadj-Bouziane, Fadila
    Ben Hamed, Suliann
    Wilson, Charles R. E.
    Procyk, Emmanuel
    Petrides, Michael
    NATURE COMMUNICATIONS, 2019, 10 (1)
  • [5] Sulcal organization in the medial frontal cortex provides insights into primate brain evolution
    Céline Amiez
    Jérôme Sallet
    William D. Hopkins
    Adrien Meguerditchian
    Fadila Hadj-Bouziane
    Suliann Ben Hamed
    Charles R. E. Wilson
    Emmanuel Procyk
    Michael Petrides
    Nature Communications, 10
  • [6] Evolution and genomics of the human brain
    Rosales-Reynoso, M. A.
    Juarez-Vazquez, C. I.
    Barros-Nunez, P.
    NEUROLOGIA, 2018, 33 (04): : 254 - 265
  • [7] Archaic hominin genomics provides a window into gene expression evolution
    Yan, Stephanie M.
    McCoy, Rajiv C.
    CURRENT OPINION IN GENETICS & DEVELOPMENT, 2020, 62 : 44 - 49
  • [8] Description of sulcal organization of the insular cortex
    Afif, Afif
    Mertens, Patrick
    SURGICAL AND RADIOLOGIC ANATOMY, 2010, 32 (05) : 491 - 498
  • [9] Description of sulcal organization of the insular cortex
    Afif Afif
    Patrick Mertens
    Surgical and Radiologic Anatomy, 2010, 32 : 491 - 498
  • [10] The Human Ventromedial Prefrontal Cortex: Sulcal Morphology and Its Influence on Functional Organization
    Lopez-Persem, Alizee
    Verhagen, Lennart
    Amiez, Celine
    Petrides, Michael
    Sallet, Jerome
    JOURNAL OF NEUROSCIENCE, 2019, 39 (19): : 3627 - 3639