Regioselective C3-H Alkylation of Imidazopyridines with Donor-Acceptor Cyclopropanes

被引：6
|
作者：
Dalkilic, Oguzhan [1 ]
Turbedaroglu, Ozge [1 ]
Lafzi, Ferruh [1 ]
Kilic, Haydar [1 ]
机构：
[1] Ataturk Univ, Fac Sci, Dept Chem, TR-25240 Erzurum, Turkiye
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 16期
关键词：
ACID; IMIDAZOHETEROCYCLES; DERIVATIVES; REACTIVITY; PROTOCOL; ION;
D O I：
10.1021/acs.joc.3c01122
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Alkylated imidazopyridines are crucial structures formedicinalchemistry. Here, an efficient method for the C3-H alkylationof imidazopyridines was devised. Under Lewis acid-catalyzed conditions,reactions of imidazopyridines with different donor-acceptorcyclopropanes were carried out. Finally, 1,3-bisfunctionalizaton ofdonor-acceptor cyclopropanes was performed. In addition, synthesizedC3-alkylated imidazopyridines are amenable for diverse synthetic applications.
引用
收藏
页码：11834 / 11846
页数：13
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