Inhibition of histone deacetylases attenuates tumor progression and improves immunotherapy in breast cancer

被引:19
|
作者
Lian, Bi [1 ]
Chen, Xiaosong [1 ]
Shen, Kunwei [1 ]
机构
[1] Shanghai Jiao Tong Univ, Ruijin Hosp, Comprehens Breast Hlth Ctr, Dept Gen Surg,Sch Med, Shanghai, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词
HDAC; inhibitors; breast cancer; immunotherapy; targets; SUBEROYLANILIDE HYDROXAMIC ACID; CELL-DEATH; IN-VITRO; CHEMOTHERAPEUTIC-AGENTS; MOCETINOSTAT MGCD0103; LBH589; PANOBINOSTAT; ANTITUMOR-ACTIVITY; ESTROGEN-RECEPTOR; HDAC INHIBITORS; VORINOSTAT;
D O I
10.3389/fimmu.2023.1164514
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Breast cancer is one of the common malignancies with poor prognosis worldwide. The treatment of breast cancer patients includes surgery, radiation, hormone therapy, chemotherapy, targeted drug therapy and immunotherapy. In recent years, immunotherapy has potentiated the survival of certain breast cancer patients; however, primary resistance or acquired resistance attenuate the therapeutic outcomes. Histone acetyltransferases induce histone acetylation on lysine residues, which can be reversed by histone deacetylases (HDACs). Dysregulation of HDACs via mutation and abnormal expression contributes to tumorigenesis and tumor progression. Numerous HDAC inhibitors have been developed and exhibited the potent anti-tumor activity in a variety of cancers, including breast cancer. HDAC inhibitors ameliorated immunotherapeutic efficacy in cancer patients. In this review, we discuss the anti-tumor activity of HDAC inhibitors in breast cancer, including dacinostat, belinostat, abexinostat, mocetinotat, panobinostat, romidepsin, entinostat, vorinostat, pracinostat, tubastatin A, trichostatin A, and tucidinostat. Moreover, we uncover the mechanisms of HDAC inhibitors in improving immunotherapy in breast cancer. Furthermore, we highlight that HDAC inhibitors might be potent agents to potentiate immunotherapy in breast cancer.
引用
收藏
页数:10
相关论文
共 50 条
  • [1] Multiple histone deacetylases repress tumor suppressor gene ARHI in breast cancer
    Feng, Weiwei
    Lu, Zhen
    Luo, Robert Z.
    Zhang, Xiaohong
    Seto, Edward
    Liao, Warren S. -L.
    Yu, Yinhua
    INTERNATIONAL JOURNAL OF CANCER, 2007, 120 (08) : 1664 - 1668
  • [2] Histone deacetylases and estrogen signalling in breast cancer
    Boulle, Nathalie
    Linares, Aurelien
    Lapierre, Marion
    Cavailles, Vincent
    CORRESPONDANCES EN METABOLISMES HORMONES DIABETES ET NUTRITION, 2011, 15 (08): : 284 - 287
  • [3] Expression levels of histone deacetylases and acetylation of histone H4 and tubulin associated with breast cancer progression
    Suzuki, J.
    Chen, Y. Y.
    DeVries, S.
    Chan, L.
    Baehner, F. L.
    Benz, C. C.
    Waldman, F. M.
    Hwang, E. S.
    CANCER RESEARCH, 2009, 69 (02) : 171S - 172S
  • [4] Inhibition of class II histone deacetylases in the spinal cord attenuates inflammatory hyperalgesia
    Bai, Guang
    Wei, Dong
    Zou, Shiping
    Ren, Ke
    Dubner, Ronald
    MOLECULAR PAIN, 2010, 6
  • [5] Anti-tumor activity of phenoxybenzamine and its inhibition of histone deacetylases
    Inchiosa, Mario A., Jr.
    PLOS ONE, 2018, 13 (06):
  • [6] Inhibition of histone deacetylases in cancer therapy: lessons from leukaemia
    Elena Ceccacci
    Saverio Minucci
    British Journal of Cancer, 2016, 114 : 605 - 611
  • [7] Inhibition of histone deacetylases in cancer therapy: lessons from leukaemia
    Ceccacci, Elena
    Minucci, Saverio
    BRITISH JOURNAL OF CANCER, 2016, 114 (06) : 605 - 611
  • [8] Pharmacological Inhibition of Endogenous Hydrogen Sulfide Attenuates Breast Cancer Progression
    Khan, Nazeer Hussain
    Wang, Di
    Wang, Wenkang
    Shahid, Muhammad
    Khattak, Saadullah
    Ngowi, Ebenezeri Erasto
    Sarfraz, Muhammad
    Ji, Xin-Ying
    Zhang, Chun-Yang
    Wu, Dong-Dong
    MOLECULES, 2022, 27 (13):
  • [9] Inhibition of class I histone deacetylases attenuates anthracycline induced activation of the ATM pathway
    Thurn, Kenneth
    Thomas, Scott
    Raha, Paromita
    Qureshi, Ian
    Munster, Pamela N.
    CANCER RESEARCH, 2011, 71
  • [10] Dysregulation of histone deacetylases in carcinogenesis and tumor progression: a possible link to apoptosis and autophagy
    Srimanta Patra
    Debasna P. Panigrahi
    Prakash P. Praharaj
    Chandra S. Bhol
    Kewal K. Mahapatra
    Soumya R. Mishra
    Bishnu P. Behera
    Mrutyunjay Jena
    Sujit K. Bhutia
    Cellular and Molecular Life Sciences, 2019, 76 : 3263 - 3282