Longitudinal trajectories of anterior cingulate glutamate and subclinical psychotic experiences in early adolescence: the impact of bullying victimization

被引：0

作者：

Okada, Naohiro ^{[1
,2
]}

Yahata, Noriaki ^{[1
,3
,4
]}

Koshiyama, Daisuke ^{[1
]}

Morita, Kentaro ^{[1
]}

Sawada, Kingo ^{[1
,5
]}

Kanata, Sho ^{[1
,6
]}

Fujikawa, Shinya ^{[1
]}

Sugimoto, Noriko ^{[1
]}

Toriyama, Rie ^{[1
]}

Masaoka, Mio ^{[1
]}

Koike, Shinsuke ^{[1
,2
,7
]}

Araki, Tsuyoshi ^{[1
,8
]}

Kano, Yukiko ^{[9
]}

Endo, Kaori ^{[10
]}

Yamasaki, Syudo ^{[10
]}

Ando, Shuntaro ^{[1
,10
]}

Nishida, Atsushi ^{[10
]}

Hiraiwa-Hasegawa, Mariko ^{[11
]}

Edden, Richard A. E. ^{[12
,13
]}

Sawa, Akira ^{[14
,15
,16
,17
,18
,19
]}

Kasai, Kiyoto ^{[1
,2
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Hongo 7-3-1,Bunkyo Ku, Tokyo 1138655, Japan

[2] Univ Tokyo, Univ Tokyo Inst Adv Study UTIAS, Int Res Ctr Neurointelligence WPI IRCN, Hongo 7-3-1,Bunkyo Ku, Tokyo 1130033, Japan

[3] Natl Inst Quantum & Radiol Sci & Technol, Inst Quantum Life Sci, Anagawa 4-9-1,Inage Ku, Chiba, Chiba 2638555, Japan

[4] Natl Inst Quantum Sci & Technol, Inst Quantum Med Sci, Dept Mol Imaging & Theranost, Anagawa 4-9-1,Inage Ku, Chiba, Chiba 2638555, Japan

[5] Univ Tokyo, Ctr Res Counseling & Support Serv, Hongo 7-3-1,Bunkyo Ku, Tokyo 1130033, Japan

[6] Teikyo Univ, Sch Med, Dept Psychiat, Kaga 2-11-1,Itabashi Ku, Tokyo 1738605, Japan

[7] Univ Tokyo, Univ Tokyo Inst Divers & Adaptat Human Mind UTIDAH, Komaba 3-8-1,Meguro Ku, Tokyo 1538902, Japan

[8] Teikyo Univ, Mizonokuchi Hosp, Dept Psychiat, Futago 5-1-1,Takatsu Ku, Kawasaki, Kanagawa 2138507, Japan

[9] Univ Tokyo, Grad Sch Med, Dept Child Neuropsychiat, Hongo 7-3-1,Bunkyo Ku, Tokyo 1138655, Japan

[10] Tokyo Metropolitan Inst Med Sci, Res Ctr Social Sci & Med, Kamikitazawa 2-1-6,Setagaya Ku, Tokyo 1568506, Japan

[11] Grad Univ Adv Studies, Sch Adv Sci, SOKENDAI, Dept Evolutionary Studies Biosyst, Hayama, Kanagawa 2400193, Japan

[12] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, 600 N Wolfe St, Baltimore, MD 21287 USA

[13] Kennedy Krieger Inst, F M Kirby Ctr Funct Brain Imaging, 707 N Broadway St, Baltimore, MD 21205 USA

[14] Johns Hopkins Univ, Sch Med, Dept Psychiat, 600 N Wolfe St, Baltimore, MD 21287 USA

[15] Johns Hopkins Univ, Sch Med, Dept Neurosci, 600 N Wolfe St, Baltimore, MD 21287 USA

[16] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, 600 N Wolfe St, Baltimore, MD 21287 USA

[17] Johns Hopkins Univ, Sch Med, Dept Genet Med, 600 N Wolfe St, Baltimore, MD 21287 USA

[18] Johns Hopkins Univ, Sch Med, Dept Pharmacol, 600 N Wolfe St, Baltimore, MD 21287 USA

[19] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mental Hlth, 600 N Wolfe St, Baltimore, MD 21287 USA

来源：

MOLECULAR PSYCHIATRY | 2024年 / 29卷 / 04期

基金：

日本学术振兴会;

关键词：

GAMMA-AMINOBUTYRIC-ACID; MAGNETIC-RESONANCE-SPECTROSCOPY; ULTRA-HIGH RISK; BRAIN GLUTAMATE; PREFRONTAL GABA; MOUSE MODEL; SCHIZOPHRENIA; CORTEX; METAANALYSIS; INDIVIDUALS;

D O I：

10.1038/s41380-023-02382-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previous studies reported decreased glutamate levels in the anterior cingulate cortex (ACC) in non-treatment-resistant schizophrenia and first-episode psychosis. However, ACC glutamatergic changes in subjects at high-risk for psychosis, and the effects of commonly experienced environmental emotional/social stressors on glutamatergic function in adolescents remain unclear. In this study, adolescents recruited from the general population underwent proton magnetic resonance spectroscopy (MRS) of the pregenual ACC using a 3-Tesla scanner. We explored longitudinal data on the association of combined glutamate-glutamine (Glx) levels, measured by MRS, with subclinical psychotic experiences. Moreover, we investigated associations of bullying victimization, a risk factor for subclinical psychotic experiences, and help-seeking intentions, a coping strategy against stressors including bullying victimization, with Glx levels. Finally, path analyses were conducted to explore multivariate associations. For a contrast analysis, gamma-aminobutyric acid plus macromolecule (GABA+) levels were also analyzed. Negative associations were found between Glx levels and subclinical psychotic experiences at both Times 1 (n = 219, mean age 11.5 y) and 2 (n = 211, mean age 13.6 y), as well as for over-time changes (n = 157, mean interval 2.0 y). Moreover, effects of bullying victimization and bullying victimization x help-seeking intention interaction effects on Glx levels were found (n = 156). Specifically, bullying victimization decreased Glx levels, whereas help-seeking intention increased Glx levels only in bullied adolescents. Finally, associations among bullying victimization, help-seeking intention, Glx levels, and subclinical psychotic experiences were revealed. GABA+ analysis revealed no significant results. This is the first adolescent study to reveal longitudinal trajectories of the association between glutamatergic function and subclinical psychotic experiences and to elucidate the effect of commonly experienced environmental emotional/social stressors on glutamatergic function. Our findings may deepen the understanding of how environmental emotional/social stressors induce impaired glutamatergic neurotransmission that could be the underpinning of liability for psychotic experiences in early adolescence.

引用

页码：939 / 950

页数：12

共 15 条

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