Essential terminology and considerations for validation of non-targeted methods

被引：6

作者：

Nichani, Kapil ^{[1
,2
]}

Uhlig, Steffen ^{[3
]}

Stoyke, Manfred ^{[4
]}

Kemmlein, Sabine ^{[4
]}

Ulberth, Franz ^{[5
]}

Haase, Ilka ^{[6
]}

Doering, Maik ^{[6
]}

Walch, Stephan G. ^{[7
]}

Gowik, Petra ^{[4
]}

机构：

[1] QuoData GmbH, Prellerstr 14, D-01309 Dresden, Germany

[2] Univ Potsdam, Inst Nutr Sci, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany

[3] QuoData GmbH, Fabeckstr 43, D-14195 Berlin, Germany

[4] Bundesamt Verbraucherschutz & Lebensmittelsicherh, Diedersdorfer Weg 1, D-12277 Berlin, Germany

[5] European Commiss, Joint Res Ctr, Retieseweg 111, B-2440 Geel, Belgium

[6] Max Rubner Inst MRI, Natl Referenzzentrum Authent Lebensmittel, Bundesforschungsinst Ernahrung & Lebensmittel, E-C Baumannstr 20, D-95236 Kulmbach, Germany

[7] Chem & Vet Untersuchungsamt CVUA Karlsruhe, Weissenburger Str 3, D-76187 Karlsruhe, Germany

来源：

FOOD CHEMISTRY-X | 2023年 / 17卷

关键词：

Non -targeted methods; Method validation; Food fraud; Food authenticity; Mass spectrometry; NMR; Spectroscopy; NGS; SCIENTIFIC CHALLENGES; FOOD; IDENTIFICATION; AUTHENTICATION; SPECTROSCOPY; NMR; FINGERPRINTS; FUTURE;

D O I：

10.1016/j.fochx.2022.100538

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Through their suggestive name, non-targeted methods (NTMs) do not aim at a predefined "needle in the hay-stack." Instead, they exploit all the constituents of the haystack. This new type of analytical method is increasingly finding applications in food and feed testing. However, the concepts, terms, and considerations related to this burgeoning field of analytical testing need to be propagated for the benefit of those associated with academic research, commercial development, or official control. This paper addresses frequently asked questions regarding terminology in connection with NTMs. The widespread development and adoption of these methods also necessitate the need to develop innovative approaches for NTM validation, i.e., evaluating the performance characteristics of a method to determine if it is fit-for-purpose. This work aims to provide a roadmap for approaching NTM validation. In doing so, the paper deliberates on the different considerations that influence the approach to validation and provides suggestions therefor.

引用

页数：12

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