Anti-inflammatory potential of some eudesmanolide and guaianolide sesquiterpenes

Ten sesquiterpene lactones isolated from Anvillea garcinii (Burm.f.) DC ethanolic extract were assessed for their anti-inflammatory potential by myeloperoxidase (MPO) activity assignment, and mice paw swelling model. 3 alpha,4 alpha-10 beta-trihydroxy-8 alpha-acetyloxyguaian-12,6 alpha-olide (1), epi-vulgarin (3), 9a-hydroxyparthenolide (4), garcinamine C (7), garcinamine D (8), garcinamine E (9), and 4, 9-dihydroxyguaian-10(14)-en-12-olide (10) showed explicit anti-inflammatory activity in rodent paw edema and MPO assignment. The findings of this study showed that the alpha-methylene gamma-lactone moiety does not always guarantee an anti-inflammatory effect, but the presence of proline at the C-3 of the lactone ring improves the binding of sesquiterpene lactones with MPO isoenzymes, resulting in a more potent inhibition.