Rare 7,9′-dinorlignans with neuroprotective activity from the roots of Lindera aggregata (Sims) Kosterm

被引：3

作者：

Liu, Qian-Qing ^{[1
]}

Xiong, Lin-An ^{[1
]}

Qian, Jia-Yu ^{[1
]}

Gong, Ting-Ting ^{[1
]}

Ma, Lie-Feng ^{[1
]}

Fang, Luo ^{[2
]}

Zhan, Zha-Jun ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Key Lab Green Pharmaceut Technol & Related Equipme, Minist Educ, Hangzhou, Peoples R China

[2] Zhejiang Canc Hosp, Dept Pharm, Hangzhou, Peoples R China

来源：

PHYTOCHEMISTRY | 2024年 / 217卷

基金：

中国国家自然科学基金;

关键词：

Lindera aggregata; Lauraceae; Dinorlignan; Ferroptosis; Neuroprotection; SESQUITERPENE LACTONES; LIGNANS; FERROPTOSIS; INHIBITION; TUBERS;

D O I：

10.1016/j.phytochem.2023.113913

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Linderagatins C-F (1-4), the first examples of naturally occurring diaryltetrahydrofuran-type 7,9 '-dinorlignans, were characterized from the roots of Lindera aggregata (Sims) Kosterm. The structures of these dinorlignans were elucidated by extensive spectroscopic analysis. The absolute configurations were determined based on calculated and experimental ECD data. A biosynthetic pathway for these dinorlignans was hypothetically proposed. Compounds 2 and 3 showed significant neuroprotective effects on erastin-induced ferroptosis in HT-22 cells with EC50 values of 23.4 and 21.8 mu M, respectively.

引用

页数：7

共 12 条

[1] Neuroprotective lindenane sesquiterpenoids from the roots of Lindera aggregata (Sims) Kosterm
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Zhan, Zha-Jun
PHYTOCHEMISTRY, 2025, 235
[2] Linderanoids A-O, dimeric sesquiterpenoids from the roots of Lindera aggregata (Sims) Kosterm
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[3] Highly oxidized guaiane 12(8),15(6)-dilactones with neuroprotective activities from the roots of Lindera aggregata (Sims) Kosterm
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[4] A new sesquiterpene isolated from Lindera aggregata (Sims) Kosterm.
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[5] One new type proanthocyanidin trimer from Lindera aggregata (Sims) Kosterm
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[6] One New A-type Proanthocyanidin Trimer from Lindera aggregata(Sims) Kosterm.
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[7] Antibacterial mechanism of polysaccharides from the leaves of Lindera aggregata (Sims) Kosterm. by metabolomics based on HPLC/MS
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[8] Analysis of Nucleosides and Amino Acids in Different Parts of Lindera aggregata (Sims) Kosterm. From Different Habitats by UFLC-QTrap-MS/MS Combined with Multivariate Statistical Analysis
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[9] Norisoboldine, a Natural Alkaloid from Lindera aggregata (Sims) Kosterm, Promotes Osteogenic Differentiation via S6K1 Signaling Pathway and Prevents Bone Loss in OVX Mice
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[10] A novel strategy by combining "magnified" matrix solid phase dispersion extraction with high-speed countercurrent chromatography for the rapid and efficient isolation of flavonoids isomers with anti-inflammatory effect from Lindera aggregata (Sims) Kosterm Leaves
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SUSTAINABLE CHEMISTRY AND PHARMACY, 2023, 33

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