Chemical constituents of the stem of Marsypopetalum modestum and their bioactivities

被引：2

作者：

Gurgul, Aleksandra ^{[1
]}

Nauman, Mirielle C. ^{[1
]}

Wu, Zhenlong ^{[2
]}

Shetye, Gauri ^{[3
]}

Ma, Rui ^{[3
]}

Youn, Isoo ^{[1
]}

Souliya, Onevilay ^{[4
]}

Bisson, Jonathan ^{[3
]}

Johnson, Jeremy J. ^{[5
]}

Che, Chun-Tao ^{[1
]}

机构：

[1] Univ Illinois, Coll Pharm, Dept Pharmaceut Sci, Chicago, IL 60607 USA

[2] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou, Peoples R China

[3] Univ Illinois, Coll Pharm, Inst TB Res, Chicago, IL USA

[4] Inst Tradit Med, Viangchan, Laos

[5] Univ Illinois, Coll Pharm, Dept Pharm Practice, Chicago, IL USA

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 21期

基金：

美国国家卫生研究院;

关键词：

Marsypopetalum modestum; lyciumphenylpropanoid B; glycosides; dipyrithione; cytotoxic activity; tuberculosis; GLYCOSIDES;

D O I：

10.1080/14786419.2022.2097229

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Phytochemical investigation of Marsypopetalum modestum (Annonaceae) led to the isolation of a new phenylpropanoid glycoside, lyciumphenylpropanoid B (10), along with nine known compounds (1-9) from an aqueous methanolic extract of the stem. Most compounds are reported from this genus for the first time. The structures of the isolated compounds were elucidated using spectroscopic methods including NMR spectroscopy, high-resolution mass spectrometry, and quantum chemical electronic circular dichroism (ECD) calculations. Cytotoxic and antitubercular activities of several isolated compounds were evaluated. Dipyrithione (1) displayed anti-mycobacterial (MIC = 0.23 mu M) and cytotoxic (IC50 = 0.8 mu M in Hep G2 cells; 4.1 mu M in HCT 116 cells) activities. Kelampayoside A (8) showed moderate cytotoxic activity against cancer cells.

引用

页码：3623 / 3630

页数：8

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