Vitamin D metabolism in cancer: potential feasibility of vitamin D metabolism blocking therapy

被引：5

作者：

Kamiya, Sakura ^{[1
]}

Nakamori, Yuna ^{[1
,2
]}

Takasawa, Akira ^{[1
]}

Takasawa, Kumi ^{[1
]}

Kyuno, Daisuke ^{[1
]}

Ono, Yusuke ^{[1
]}

Magara, Kazufumi ^{[1
]}

Osanai, Makoto ^{[1
]}

机构：

[1] Sapporo Med Univ, Dept Pathol, Sch Med, South-1,West-17,Chuo Ku, Sapporo 0600061, Japan

[2] Sapporo Med Univ, Dept Oral Surg, Sch Med, Sapporo, Japan

来源：

MEDICAL MOLECULAR MORPHOLOGY | 2023年 / 56卷 / 02期

关键词：

Cancer; Vitamin D; Oncogenic property; Anticancer drugs; Vitamin D metabolism-blocking therapy; D-RECEPTOR EXPRESSION; PROSTATE-CANCER; EPIGENETIC REGULATION; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; ANTIPROLIFERATIVE ACTIVITY; D; 24-HYDROXYLASE/CYP24A1; PROMOTER METHYLATION; ANTITUMOR-ACTIVITY; COLORECTAL-CANCER; COPY-NUMBER;

D O I：

10.1007/s00795-023-00348-x

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this review, we discuss the possibility of the vitamin D metabolizing enzyme CYP24A1 being a therapeutic target for various tumors including breast, colorectal and prostate tumors. Given the pleiotropic cellular activity of vitamin D, its deficiency impairs its physiological function in target cells and results in various pathologies including cancer. In addition, accumulated data have shown that elevated expression of CYP24A1 promotes carcinogenesis in various cancer subtypes by decreasing the bioavailability of vitamin D metabolites. Thus, we propose the potential feasibility of vitamin D metabolism-blocking therapy in various types of human malignancies that express constitutive CYP24A1.

引用

页码：85 / 93

页数：9

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