Carbon quantum dots as drug carriers for tumor-associated macrophage repolarization following photothermal therapy

被引:1
|
作者
Yuan, Haizhong [1 ]
Yang, Hui [2 ]
Yuan, Pin [3 ]
Wang, Tingting [4 ]
Zhou, Quan [3 ]
机构
[1] PKU Care Luan Hosp, Pharm Dept, Shanxi 046204, Peoples R China
[2] Changzhi Med Coll, Dept Publ Hlth & Prevent Med, Shanxi 046000, Peoples R China
[3] Nanjing Jiatong Micronano Technol Co Ltd, Jiangsu 210000, Peoples R China
[4] Nanjing Seth Technol Serv Co Ltd, Jiangsu 210043, Peoples R China
来源
SCIENCEASIA | 2023年 / 49卷 / 04期
关键词
photothermal therapy; tumor-associated macrophages; carbon quantum dots; immunocompetent M1 phenotype; PHOTODYNAMIC THERAPY; LASER; PAIN;
D O I
10.2306/scienceasia1513-1874.2023.060
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
With the development of nanotechnology in the anticancer application, photothermal therapy (PTT) based on nanoparticles (NPs) could repolarize the tumor-associated macrophages (TAMs) from protumor (M2) phenotype to antitumor (M1) phenotype, thus regulating the tumor-suppressive immune environment. However, the inevitable local inflammation occurred in the residual tumor microenvironment after PTT recruited abundant abnormal TAMs to induce immune escape and survival of the remaining tumor cells. Here, TMP195 loaded carbon quantum dots (CQDs@TMP195) were developed as innovative nanoplatforms to achieve promising PTT and immune responses. In the nanoplatforms, CQDs with distinct antitumor performance were applied as an ideal drug-loading nanocarrier and initiated photothermal effects to generate heat under near-infrared (NIR) irradiation. The loaded TMP195 could repolarize the M2 phenotype TAMs into the M1 phenotype TAMs. Based on our work, the in vitro antitumor effects implied that CQDs@TMP195 could significantly kill cancer cells with minimal toxicity to normal cells. This study proposes a feasible therapeutic strategy for polarizing TAMs to the immunocompetent M1 phenotype after PTT.
引用
收藏
页码:627 / 634
页数:8
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