Cardiolipin-Mediated Alleviation of Mitochondrial Dysfunction Is a Neuroprotective Effect of Statin in Animal Model of Ischemic Stroke

被引:9
|
作者
Sarmah, Deepaneeta [1 ]
Sarkar, Abhishek [1 ,2 ]
Datta, Aishika [1 ]
Ghosh, Bijoyani [1 ]
Rana, Nikita [1 ]
Sahu, Shubhrakanta [1 ]
Gupta, Vishal [1 ]
Thongire, Vrushali [1 ]
Chaudhary, Antra [1 ]
Vadak, Namrata [1 ]
Kaur, Harpreet [1 ]
Raut, Swapnil [1 ]
Singh, Upasna [1 ]
Borah, Anupom [3 ]
Bhattacharya, Pallab [1 ]
机构
[1] Natl Inst Pharmaceut Educ & Res NIPER, Pharmacol & Toxicol, Gandhinagar 382355, Gujarat, India
[2] Natl Inst Pharmaceut Educ & Res NIPER SAS Nagar, Mohali 160062, Punjab, India
[3] Assam Univ, Dept Life Sci & Bioinformat, Cellular & Mol Neurobiol Lab, Silchar 788011, Assam, India
来源
ACS CHEMICAL NEUROSCIENCE | 2023年
关键词
ischemic stroke; mitochondria; simvastatin; pleiotropic effect; cardiolipin; neuroprotection; ENDOPLASMIC-RETICULUM STRESS; CEREBRAL-ARTERY OCCLUSION; RATS; SIMVASTATIN; PREVENTION; ASSOCIATION; REDUCTION; THERAPY; MUSCLE; LIVER;
D O I
10.1021/acschemneuro.2c00645
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In clinical settings, the benefit of statin for stroke is debatable as regular statin users may suffer from myalgia, statin-associated myopathy (SAM), and rarely rhabdomyolysis. Studies suggest that patients on statin therapy show lesser vulnerability toward ischemic stroke and post-stroke frailty. Both pre-and post-treatment benefits of statin have been reported as evident by its neuroprotective effects in both cases. As mitochondrial dysfunction following stroke is the fulcrum for neuronal death, we hereby explore the role of statin in alleviating mitochondrial dysfunction by regulating the mitochondrial dynamics. In the present study, we intend to evaluate the role of statin in modulating cardiolipin-mediated mitochondrial functionality and further providing a therapeutic rationale for repurposing statins either as preventive or an adjunctive therapy for stroke.
引用
收藏
页码:709 / 724
页数:16
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