Synthesis and antimicrobial activity of new glucosamine derivatives

被引：0

作者：

Anh, Le Duc ^{[1
]}

Bao, Ninh Duc ^{[2
]}

Duc, Le Viet ^{[3
]}

Van Chinh, Luu ^{[4
]}

Cuong, Nguyen Manh ^{[4
]}

Thuy, Dinh Thi Thu ^{[4
]}

Hung, Truong Ngoc ^{[4
]}

机构：

[1] Mil Inst Sci & Technol, Inst Chem & Mat, 17 Hoang Sam, Hanoi 10000, Vietnam

[2] Truman State Univ, Kirksville, MO 63501 USA

[3] Hanoi Univ Sci & Technol, Sch Chem Engn, 1 Dai Co Viet, Hanoi 10000, Vietnam

[4] Vietnam Acad Sci & Technol, Inst Nat Prod Chem, 18 Hoang Quoc Viet, Hanoi 10000, Vietnam

来源：

VIETNAM JOURNAL OF CHEMISTRY | 2023年 / 61卷 / S2期

关键词：

D-glucosamine; murrayafoline A; acridone; amides; antimicrobial; DESIGN;

D O I：

10.1002/vjch.202300092

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this study, a series of reactions were used to protect and deprotect hydroxyl and amine groups of D-glucosamine which was obtained by the hydrolysis of chitin in concentrated HCl. Amidation of this protected monomer with aromatic and heteroaromatic acids was carried out in dichloromethane in the presence of DCC as a coupling reagent to produce new amides in good yields. Their structures were determined by NMR and MS spectra while their antifungal and antibacterial activities were screened.

引用

页码：124 / 130

页数：7

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