Using BCG vaccination to protect against COVID-19: when reality fails to meet expectation

被引：5
|
作者：
Pittet, Laure F. [1 ,2 ,3 ]
Noble, Christie C. A. [1 ,2 ,4 ]
Messina, Nicole L. [1 ,2 ]
Curtis, Nigel [1 ,2 ,4 ]
机构：
[1] Univ Melbourne, Dept Paediat, Parkville, Vic, Australia
[2] Murdoch Childrens Res Inst, Parkville, Vic, Australia
[3] Geneva Univ Hosp, Fac Med, Immunol Vaccinol & Paediat Infect Dis Unit, Geneva, Switzerland
[4] Royal Childrens Hosp Melbourne, Infect Dis, Parkville, Vic, Australia
来源：
NATURE REVIEWS IMMUNOLOGY | 2024年 / 24卷 / 02期
关键词：
TRIAL;
D O I：
10.1038/s41577-024-00992-z
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
While anticipating the development of a COVID-19-specific vaccine, several randomized controlled trials (RCTs) explored the potential of BCG vaccination to protect against COVID-19, based on trials demonstrating beneficial effects of BCG vaccination on unrelated infections and all-cause mortality in neonates in high-mortality geographical settings. Results are now available from 12 RCTs, which suggest that BCG vaccination is not an effective intervention against COVID-19. That the BCG-COVID-19 trials failed to meet expectation emphasizes the importance of rigorous clinical trials to validate hypotheses, even in urgent situations such as a pandemic.
引用
收藏
页码：83 / 84
页数：2
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