a-synuclein as a promising biomarker for developing diagnostic tools against neurodegenerative synucleionopathy disorders

被引:5
|
作者
Bagree, Gayatri [1 ,2 ,3 ]
De Silva, Oshadie [1 ]
Liyanage, Piyumi Dinusha [1 ]
Ramarathinam, Sri Harsha [4 ]
Sharma, Sandeep K. [2 ,3 ]
Bansal, Vipul [1 ]
Ramanathan, Rajesh [1 ]
机构
[1] RMIT Univ, Sch Sci, NanoBiotechnol Res Lab NBRL, Ian Potter NanoBioSensing Facil, GPO Box 2476, Melbourne, Vic 3001, Australia
[2] CSIR Indian Inst Toxicol Res, Food Drug & Chem Toxicol Grp, Vishvigyan Bhawan 31,Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India
[3] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, Uttar Pradesh, India
[4] Monash Univ, Biomed Discovery Inst, Dept Biochem & Mol Biol, Infect & Immun Program, Clayton, Vic 3800, Australia
基金
澳大利亚研究理事会;
关键词
a-synuclein; Neurodegenerative disorder; Biomarker; MRE; Biosensor; Diagnostics; Synucleinopathies; PHOSPHORYLATED ALPHA-SYNUCLEIN; MULTIPLE SYSTEM ATROPHY; PARKINSONS-DISEASE; CEREBROSPINAL-FLUID; LEWY BODIES; POTENTIAL BIOMARKER; NANOZYME ACTIVITY; ELEVATED LEVELS; BLOOD-CELLS; PLASMA;
D O I
10.1016/j.trac.2023.116922
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Synucleinopathies are multifactorial neurodegenerative disorders marked by the presence of intracel-lular deposits of a-synuclein (a-syn) protein. Although significant progress has been made in under-standing the pathogenesis of synucleinopathies, diagnosis largely relies on the clinical symptoms and histopathological analyses. A major challenge is the lack of diagnostic tests for identifying disease bio-markers. As aggregation of a-syn is one of the key indicators of disease, this protein is of interest as a target biomarker for the development of diagnostic platforms. In this review, we outline emerging ev-idence that highlights the importance of a-syn as a reliable biomarker for synucleinopathies. We present a comprehensive overview of the underlying principle of different methods available for the detection of a-syn which either use molecular recognition elements (MREs) to obtain specificity, or direct detection where specificity is obtained by using sensor components. Finally, the review provides a critical outlook on the current trends and challenges in a-syn based disease diagnosis and makes recommendations for the steps needed to achieve full diagnostic potential of the available methods.(c) 2023 Elsevier B.V. All rights reserved.
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页数:17
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