Characteristics and pathogenesis of chemokines in the post-stroke stage

被引：2
|
作者：
Lin, Yu-ting [1 ,2 ]
Chen, Hao-dong [1 ,2 ]
Ai, Qi-di [1 ,2 ]
Yang, Yan-tao [1 ,2 ]
Zhang, Zhao [3 ,4 ]
Chu, Shi-feng [3 ,4 ]
Chen, Nai-hong [1 ,2 ,3 ,4 ]
机构：
[1] Hunan Univ Chinese Med, Coll Pharm, Hunan Engn Technol Ctr Standardizat & Funct Chines, Changsha 410208, Peoples R China
[2] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Peoples R China
[3] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
[4] Chinese Acad Med Sci & Peking Union Med Coll, Neurosci Ctr, Beijing 100050, Peoples R China
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2023年 / 116卷
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
Stroke; Chemokine; Chemokine receptor; Nerve repair; CEREBRAL-ISCHEMIA-REPERFUSION; BINDING PROTEIN; INTRACEREBRAL HEMORRHAGE; INFLAMMATORY RESPONSE; SIGNALING PATHWAY; STROKE RECOVERY; FOCAL ISCHEMIA; BRAIN-INJURY; EXPRESSION; CC;
D O I：
10.1016/j.intimp.2023.109781
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Chemokines, as small molecular proteins, play a crucial role in the immune and inflammatory responses after stroke. A large amount of evidence showed chemokines and their receptors were increasingly recognized as potential targets for stroke treatment, which were involved in the processing of neovascularization, neurogenesis, and neural network reconstruction. In this review, we summarized the characteristics of chemokine alterations throughout the post-stroke nerve repair phase to gain insight into the pathological mechanisms of chemokines and find effective therapeutic targets for stroke.
引用
收藏
页数：12
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