This article analyzes the impact of the 1814 epidemic of fevers or typhus in the Tlax-calan Indian villages of the northeast, in the cases of San Esteban, Santa Maria de las Parras, San Francisco de Tlaxcala, San Miguel de Aguayo, and El alamo. This epidemic was one of the deadliest ever recorded, compared to other cases in the northeast. Due to its intensity, it was one of the factors that diminished the population of the Tlaxcalan villages and helped to dilute their identity, coupled with the Gaditan liber-alism, which was making the system of estates and privileges obsolete for the sake of equality before the law.