The correlation between serum 1, 5-anhydroglucitol and β-cell function in Chinese adults with different glucose metabolism statuses

被引：0
|
作者：
Yuan, Yuexing [1 ]
Tan, Yuanyuan [1 ,2 ]
Wang, Yao [1 ]
Qiu, Shanhu [1 ]
Yang, Jiao [1 ]
Chen, Cheng [1 ]
机构：
[1] Southeast Univ, Zhongda Hosp, Med Sch, Dept Endocrinol,Inst Diabet, Nanjing 210009, Peoples R China
[2] Jiaxing Matern & Child Hlth Care Hosp, Jiaxing 314000, Peoples R China
来源：
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES | 2024年 / 44卷 / 04期
关键词：
1; 5-anhydroglucitol; beta-cell function; Diabetes; Glucose metabolism status; FASTING PLASMA-GLUCOSE; INSULIN-RESISTANCE; URIC-ACID; INTRAVENOUS GLUCOSE; GLYCATED HEMOGLOBIN; DIABETES-MELLITUS; 1,5-ANHYDROGLUCITOL; SECRETION; DYSFUNCTION; TOLERANCE;
D O I：
10.1007/s13410-023-01295-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective Serum 1, 5-AG is a glycaemic marker reflecting control and fluctuations of short-term glucose. To reveal the relationship between 1, 5-AG with beta-cell function, we investigated a certain number of Chinese adults with different glucose metabolisms.Methods In clinical cross-sectional study, 2184 subjects with no prior diabetes history are included and underwent an OGTT. HOMA-IR and HOMA-beta were calculated. Correlations between 1, 5-AG and HOMA-IR or HOMA-beta were observed, correcting for interference factors, and independent factors for HOMA-beta and HOMA-IR were analysed. Subjects were divided into three groups according to OGTT results, and 1, 5-AG levels differed significantly between them.Results A significant positive correlation existed between 1, 5-AG and HOMA-beta only in the diabetes mellitus group (r = 0.265, p < 0.001). Above phenomenon remained after adjusting for indicators, however, disappeared after considering serum uric acid. Both 1, 5-AG and HbA1c were independent factors for HOMA-beta (1, 5-AG: beta = 0.772, p = 0.023; HbA1c: beta = -7.52, p = 0.003). Conclusion: 1, 5-AG remained a factor for HOMA-beta only for those with NUA. 1, 5-AG reflects different glucose metabolism statuses and is an auxiliary observation reflecting the secretory function of beta cells in NUA patients.
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收藏
页码：799 / 805
页数：7
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