In this article, we study a class of closed connected orientable PL 4-manifolds admitting a semi-simple crystallization and which have an infinite cyclic fundamental group. We showthat themanifold in the class admits a handle decomposition in which the number of 2-handles depends upon its second Betti number and other hhandles ( h <= 4) are at most 2. More precisely, our main result is the following. For a closed connected orientable PL 4-manifold having a semi-simple crystallization with the fundamental group as Z, we have constructed a handle decomposition for M as one of the following types: (1) one 0-handle, two 1-handles, 1 + beta(2)( M) 2-handles, one 3-handle and one 4-handle, (2) one 0-handle, one 1-handle, beta(2)(M) 2-handles, one 3-handle and one 4-handle, where beta(2)( M) denotes the second Betti number of manifold M with Z coefficients.