Local injection of micro-dose guselkumab for palmoplantar pustulosis after partial failure of systemic ixekizumab treatment

被引：0

作者：

Zhou, Chaojing ^{[1
]}

Chen, Dandan ^{[1
]}

Diao, Ziyue ^{[1
]}

Wang, Yufei ^{[1
]}

Hou, Yiyun ^{[1
]}

Yin, ZhiQiang ^{[1
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Dermatol, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China

来源：

AUSTRALASIAN JOURNAL OF DERMATOLOGY | 2024年 / 65卷 / 03期

基金：

中国国家自然科学基金;

关键词：

biologics; palmoplantar pustulosis; paradoxical reaction; psoriasis; therapy;

D O I：

10.1111/ajd.14244

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We present a palmoplantar pustulosis case partially resistant to systemic IL-17A inhibitor (ixekizumab) treatment, and then receiving a local injection of 0.1 mL micro-dose (1 mg) IL-23 inhibitor (guselkumab) every 4 weeks for four times. The paradoxical lesion disappeared rapidly following local injection and there was no recurrence after 8 weeks of drug withdrawal. This is the first clinical report on the treatment of palmoplantar pustulosis by local injection of micro-dose guselkumab.

引用

页码：e75 / e76

页数：2

共 11 条

[1] Local injection of micro-dose guselkumab for acrodermatitis continua of Hallopeau after failure of systemic ixekizumab treatment
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[2] Local injection of micro-dose anti-interleukin-17A antibody for palmoplantar pustulosis: A real-world study
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[3] Local injection of low-dose ixekizumab for the treatment of palmoplantar pustular psoriasis
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