The roles of tissue resident macrophages in health and cancer

被引：11

作者：

Cao, Minmin ^{[1
]}

Wang, Zihao ^{[2
,3
]}

Lan, Wanying ^{[2
,4
]}

Xiang, Binghua ^{[2
,3
]}

Liao, Wenjun ^{[2
]}

Zhou, Jie ^{[2
]}

Liu, Xiaomeng ^{[2
]}

Wang, Yiling ^{[2
]}

Zhang, Shichuan ^{[2
]}

Lu, Shun ^{[2
]}

Lang, Jinyi ^{[2
]}

Zhao, Yue ^{[2
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Sch Basic Med Sci, Chengdu, Peoples R China

[2] Univ Elect Sci & Technol China, Dept Radiat Oncol,Affiliated Canc Hosp, Radiat Oncol Key Lab Sichuan Prov,Sichuan Canc Ctr, Sichuan Clin Res Ctr Canc,Sichuan Canc Hosp & Inst, Chengdu, Peoples R China

[3] Univ Elect Sci & Technol China, Sch Med, Chengdu, Peoples R China

[4] Guixi Community Hlth Ctr Chengdu High Tech Zone, Chengdu, Peoples R China

来源：

EXPERIMENTAL HEMATOLOGY & ONCOLOGY | 2024年 / 13卷 / 01期

关键词：

Tissue resident macrophages; Bone-marrow derived macrophages; Monocytes; Homeostasis; Cancer; TUMOR-ASSOCIATED MACROPHAGES; COLONY-STIMULATING FACTOR; DENDRITIC CELL SUBSETS; LANGERHANS CELLS; INTESTINAL MACROPHAGES; GLIOBLASTOMA INVASION; THERAPEUTIC TARGET; DERMAL MACROPHAGES; BRAIN METASTASIS; MICROGLIA EMERGE;

D O I：

10.1186/s40164-023-00469-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

As integral components of the immune microenvironment, tissue resident macrophages (TRMs) represent a self-renewing and long-lived cell population that plays crucial roles in maintaining homeostasis, promoting tissue remodeling after damage, defending against inflammation and even orchestrating cancer progression. However, the exact functions and roles of TRMs in cancer are not yet well understood. TRMs exhibit either pro-tumorigenic or anti-tumorigenic effects by engaging in phagocytosis and secreting diverse cytokines, chemokines, and growth factors to modulate the adaptive immune system. The life-span, turnover kinetics and monocyte replenishment of TRMs vary among different organs, adding to the complexity and controversial findings in TRMs studies. Considering the complexity of tissue associated macrophage origin, macrophages targeting strategy of each ontogeny should be carefully evaluated. Consequently, acquiring a comprehensive understanding of TRMs' origin, function, homeostasis, characteristics, and their roles in cancer for each specific organ holds significant research value. In this review, we aim to provide an outline of homeostasis and characteristics of resident macrophages in the lung, liver, brain, skin and intestinal, as well as their roles in modulating primary and metastatic cancer, which may inform and serve the future design of targeted therapies.

引用

页数：22