Expression and prognostic value of Cripto-1 in early non-small cell lung cancer

被引：1

作者：

Zhong, Jian ^{[1
]}

Li, Li ^{[2
,3
]}

Zhang, Qian ^{[2
,3
]}

Zou, Jue ^{[4
]}

Liu, Wei ^{[2
]}

Xu, Chun Hua ^{[2
,3
]}

机构：

[1] Nanjing Med Univ, Affiliated Nanjing Brain Hosp, Dept Thorac Surg, Nanjing, Peoples R China

[2] Nanjing Med Univ, Affiliated Nanjing Brain Hosp, Dept Resp Med, 215 Guangzhou Rd, Nanjing 210029, Peoples R China

[3] Clin Ctr Nanjing Resp Dis & Imaging, Nanjing, Peoples R China

[4] Nanjing Med Univ, Affiliated Nanjing Brain Hosp, Dept Pathol, Nanjing, Peoples R China

来源：

CLINICAL RESPIRATORY JOURNAL | 2023年 / 17卷 / 12期

关键词：

Cripto-1; NSCLC; prognosis; recurrence; MESENCHYMAL TRANSITION; ADJUVANT CHEMOTHERAPY; SUBPOPULATION; PROGRESSION; MELANOMA; PROMOTES; MARKER; GROWTH;

D O I：

10.1111/crj.13680

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

ObjectiveWe aim to explore the expression of Cripto-1 (CR-1) protein in patients with early stage non-small cell lung cancer (NSCLC). MethodsWe investigated CR-1 expression status in specimens obtained from 240 patients with resected NSCLC and 30 cases of para-carcinous normal lung tissues. ResultsCompared with normal lung tissue, the positive expression of CR-1 protein in NSCLC was significantly increased (p < 0.005). Cox multivariate regression analysis showed that the expression of CR-1 protein was an independent prognostic factor for early stage NSCLC (p = 0.002). ConclusionDetecting CR-1 protein can predict the prognosis and recurrence in patients with NSCLC.

引用

页码：1203 / 1208

页数：6

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