Levels of Anti-FVIII IgG4 and Total IgG Are Biomarkers of Immune Tolerance Induction Failure in Patients with Inherited Hemophilia a and High-Responding Inhibitors

被引：0

作者：

Rezende, Suely Meireles ^{[1
]}

Ayala, Brendon ^{[1
]}

Camelo, Ricardo ^{[1
]}

Dias, Maise M. ^{[2
]}

Oliveira, Andrea G. ^{[3
]}

Franco, Vivian K. B. ^{[4
]}

Cerqueira, Monica H. ^{[5
]}

Lorenzato, Claudia S. ^{[6
]}

Ribeiro, Rosangela A. ^{[7
]}

Callado, Fabia M. R. A. ^{[8
]}

Cerqueira, Maria Aline ^{[9
]}

Etto, Leina Y. ^{[10
]}

Roberti, Maria do Rosario ^{[11
,12
]}

Anegawa, Tania H. ^{[13
,14
]}

Pinto, Ieda ^{[15
]}

Chaves, Daniel Goncalves ^{[16
]}

机构：

[1] Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil

[2] Univ Sao Paulo, Ribeirao Preto, Brazil

[3] Fundacao Hemominas, Belo Horizonte, MG, Brazil

[4] Ctr Hematol & Hemoterapia Santa Catarina HEMOSC, Florianopolis, SC, Brazil

[5] Inst Hematol Estado Rio De Janeiro HEMORIO, Rio De Janeiro, Brazil

[6] Hemoctr Parana HEMEPAR, Curitiba, Parana, Brazil

[7] Univ Fed Ceara, Fortaleza, Ceara, Brazil

[8] Fundacao Hematol & Hemoterapia Pernambuco HEMOPE, Recife, PE, Brazil

[9] Ctr Hematol & Hemoterapia Piaui HEMOPI, Teresina, Brazil

[10] Hemoctr Paraiba HEMOIBA, Joao Pessoa, Paraiba, Brazil

[11] Univ Fed Goias, Goiania, Go, Brazil

[12] Hemoctr Goias HEMOGO, Goiania, Go, Brazil

[13] Univ Estadual Londrina, Fac Med, Londrina, Parana, Brazil

[14] Ctr Hematol Reg Londrina HEMEPAR Londrina, Londrina, Parana, Brazil

[15] Hemoctr Para, Belem, Para, Brazil

[16] Fundacao HEMOMINAS, Belo Horizonte, MG, Brazil

来源：

BLOOD | 2023年 / 142卷

关键词：

D O I：

10.1182/blood-2023-189031

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页数：4

共 29 条

[1] IgG subclasses of anti-FVIII antibodies during immune tolerance induction in patients with hemophilia A
van Helden, Pauline M. W.
van den Berg, H. Marijke
Gouw, Samantha C.
Kaijen, Paul H. P.
Zuurveld, Marleen G.
Mauser-Bunschoten, Evelien P.
Aalberse, Rob C.
Vidarsson, Gestur
Voorberg, Jan
BRITISH JOURNAL OF HAEMATOLOGY, 2008, 142 (04) : 644 - 652
[2] TOLERANCE INDUCTION IN HIGH-RESPONDING HEMOPHILIACS WITH FVIII ANTIBODIES BY MEANS OF COMBINED TREATMENT WITH IGG, CYCLOPHOSPHAMIDE AND FVIII
NILSSON, IM
BERNTORP, E
ZETTERVALL, O
THROMBOSIS AND HAEMOSTASIS, 1987, 58 (01) : 519 - 519
[3] IgG subclasses of anti-FVIII antibodies during immune tolerance induction in patients with hemophilia (vol 142, pg 644, 2008)
van Helden, P. M. W.
van den Berg, H. M.
Gouw, S. C.
Kaijen, P. H. P.
Zuurveld, M. G.
Mauser-Bunschoten, E. P.
Aalberse, R. C.
Vidarsson, G.
Voorberg, J.
BRITISH JOURNAL OF HAEMATOLOGY, 2009, 144 (04) : 625 - 625
[4] HIGH THROUGHPUT GENERATION AND CHARACTERIZATION OF MONOCLONAL ANTI-FVIII IGG FROM PATIENTS WITH HEMOPHILIA A
Lacroix-Desmazes, S.
HAEMOPHILIA, 2020, 26 : 18 - 19
[5] High levels of anti-factor VIII immunoglobulin G4 and immunoglobulin G total are associated with immune tolerance induction failure in people with congenital hemophilia A and high-responding inhibitors
Chaves, Daniel Goncalves
da Silva Santos, Brendon Ayala
Zucherato, Luciana Werneck
Dias, Maise Moreira
Lorenzato, Claudia Santos
de Oliveira, Andrea Goncalves
Cerqueira, Monica Hermida
Ribeiro, Rosangela de Albuquerque
Etto, Leina Yukari
Brognoli Franco, Vivian Karla
Ferraz Roberti, Maria do Rosario
Rodrigues de Araujo Callado, Fabia Michelle
Ferreira de Cerqueira, Maria Aline
Pinto, Ieda
Camelo, Ricardo Mesquita
Rezende, Suely Meireles
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS, 2024, 8 (04)
[6] Evaluation of Predictors of Outcome in Immune Tolerance Induction Treatment of Hemophilia. Patients with High-Responding Inhibitors
Prezotti, Alessandra N. L.
Ferreira, Clarissa
Oliveira, Luciana
Lorenzato, Claudia
Orletti, Maria P. S. V.
Roberti, Maria do Rosario
Ribeiro, Rosangela
Villaca, Paula Ribeiro
Montalvao, Silmara Aparecida De Lima
Medina, Samuel S.
Hayakawa, Gabriela G. Yamaguti
Ozelo, Margareth C.
BLOOD, 2017, 130
[7] Predictors of success of immune tolerance induction in hemophilia A patients with high-responding inhibitors: A score from the Italian registry
Coppola, A.
Margaglione, M.
Santagostino, E.
Rocino, A.
Tagliaferri, A.
Messina, M.
Zanon, E.
Linari, S.
Iorio, A.
Valdre, L.
Mancuso, M.
Di Minno, G.
HAEMOPHILIA, 2012, 18 : 85 - 85
[8] IgG4 Subclass of Anti-FVIII Antibodies is Correlated to High-Titer Inhibitor, whereas IgG1 Subclass is Related to Low-Titer Inhibitor in Hemophilia A Patients
Montalvao, S.
Trento, T.
Veiga, M.
Montenegro, M.
Streva, A.
De Paula, E.
Colella, M.
Ozelo, M.
HAEMOPHILIA, 2012, 18 : 92 - 93
[9] A longitudinal evaluation of anti-FVIII antibodies demonstrated IgG4 subclass is mainly correlated with high-titre inhibitor in haemophilia A patients
Montalvao, S. A. L.
Tucunduva, A. C.
Siqueira, L. H.
Sambo, A. L. A.
Medina, S. S.
Ozelo, M. C.
HAEMOPHILIA, 2015, 21 (05) : 686 - 692
[10] Predictors of success of immune tolerance induction in hemophilia a patients with high-responding inhibitors. A prognostic score from the Italian profit registry
Coppola, A.
Margaglione, M.
Rocino, A.
Mancuso, M. E.
Tagliaferri, A.
Zanon, E.
Santoro, R.
Schinco, P.
Linari, S.
Castaman, G.
Messina, M.
Cultrera, D.
Santoro, C.
Biasoli, C.
Santagostino, E.
Minno, G. D.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2015, 13 : 79 - 79

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