Viral vectors have been proven useful in a broad spectrum of gene therapy applications due to their possibility to accommodate foreign genetic material for both local and systemic delivery. The wide range of viral vectors has enabled gene therapy applications for both acute and chronic diseases. Cancer gene therapy has been addressed by the delivery of viral vectors expressing anti-tumor, toxic, and suicide genes for the destruction of tumors. Delivery of immunostimulatory genes such as cytokines and chemokines has also been applied for cancer therapy. Moreover, oncolytic viruses specifically replicating in and killing tumor cells have been used as such for tumor eradication or in combination with tumor killing or immunostimulatory genes. In a broad meaning, vaccines against infectious diseases and various cancers can be considered gene therapy, which has been highly successful, not the least for the development of effective COVID-19 vaccines. Viral vector-based gene therapy has also demonstrated encouraging and promising results for chronic diseases such as severe combined immunodeficiency (SCID), muscular dystrophy, and hemophilia. Preclinical gene therapy studies in animal models have demonstrated proof-of-concept for a wide range of disease indications. Clinical evaluation of drugs and vaccines in humans has showed high safety levels, good tolerance, and therapeutic efficacy. Several gene therapy drugs such as the adenovirus-based drug Gendicine(R) for non-small-cell lung cancer, the reovirus-based drug Reolysin(R) for ovarian cancer, lentivirus-based treatment of SCID-X1 disease, and the rhabdovirus-based vaccine Ervebo against Ebola virus disease, and adenovirus-based vaccines against COVID-19 have been developed.
机构:
Natl Engn Technol Res Ctr Combined Vaccines, Wuhan 430207, Peoples R China
Wuhan Inst Biol Prod Co Ltd, Wuhan 430207, Peoples R ChinaNatl Engn Technol Res Ctr Combined Vaccines, Wuhan 430207, Peoples R China
Li, Xuedan
Le, Yang
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Natl Engn Technol Res Ctr Combined Vaccines, Wuhan 430207, Peoples R China
Wuhan Inst Biol Prod Co Ltd, Wuhan 430207, Peoples R ChinaNatl Engn Technol Res Ctr Combined Vaccines, Wuhan 430207, Peoples R China
Le, Yang
Zhang, Zhegang
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Natl Engn Technol Res Ctr Combined Vaccines, Wuhan 430207, Peoples R China
Wuhan Inst Biol Prod Co Ltd, Wuhan 430207, Peoples R ChinaNatl Engn Technol Res Ctr Combined Vaccines, Wuhan 430207, Peoples R China
Zhang, Zhegang
Nian, Xuanxuan
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Natl Engn Technol Res Ctr Combined Vaccines, Wuhan 430207, Peoples R China
Wuhan Inst Biol Prod Co Ltd, Wuhan 430207, Peoples R ChinaNatl Engn Technol Res Ctr Combined Vaccines, Wuhan 430207, Peoples R China
Nian, Xuanxuan
Liu, Bo
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Natl Engn Technol Res Ctr Combined Vaccines, Wuhan 430207, Peoples R China
Wuhan Inst Biol Prod Co Ltd, Wuhan 430207, Peoples R ChinaNatl Engn Technol Res Ctr Combined Vaccines, Wuhan 430207, Peoples R China
Liu, Bo
Yang, Xiaoming
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Natl Engn Technol Res Ctr Combined Vaccines, Wuhan 430207, Peoples R China
Wuhan Inst Biol Prod Co Ltd, Wuhan 430207, Peoples R China
China Natl Biotech Grp Co Ltd, Beijing 100029, Peoples R ChinaNatl Engn Technol Res Ctr Combined Vaccines, Wuhan 430207, Peoples R China
机构:
Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept intens care unit, 3 Qingchun East Rd, Hangzhou 310020, Peoples R China
Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Intens Care Unit, 3 Qingchun East Rd, Hangzhou 310020, Peoples R ChinaZhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept intens care unit, 3 Qingchun East Rd, Hangzhou 310020, Peoples R China
Zhang, Jian
Wang, Tingting
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Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept intens care unit, 3 Qingchun East Rd, Hangzhou 310020, Peoples R ChinaZhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept intens care unit, 3 Qingchun East Rd, Hangzhou 310020, Peoples R China
Wang, Tingting
Zheng, Rui
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Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept intens care unit, 3 Qingchun East Rd, Hangzhou 310020, Peoples R ChinaZhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept intens care unit, 3 Qingchun East Rd, Hangzhou 310020, Peoples R China
Zheng, Rui
Wang, Xingxing
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Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept intens care unit, 3 Qingchun East Rd, Hangzhou 310020, Peoples R ChinaZhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept intens care unit, 3 Qingchun East Rd, Hangzhou 310020, Peoples R China
机构:
Int Univ Sarajevo, Fac Engn & Nat Sci, Dept Genet & Bioengn, Sarajevo 71000, Bosnia & HercegInt Univ Sarajevo, Fac Engn & Nat Sci, Dept Genet & Bioengn, Sarajevo 71000, Bosnia & Herceg
Hromic-Jahjefendic, Altijana
Lundstrom, Kenneth
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机构:
PanTherapeutics, CH-1095 Lutry, SwitzerlandInt Univ Sarajevo, Fac Engn & Nat Sci, Dept Genet & Bioengn, Sarajevo 71000, Bosnia & Herceg
机构:
Imperial Coll London, Fac Med, Dept Brain Sci, Div Neurosci, London, EnglandImperial Coll London, Fac Med, Dept Brain Sci, Div Neurosci, London, England
Pickering, Ceri A.
Mazarakis, Nicholas D.
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Imperial Coll London, Fac Med, Dept Brain Sci, Div Neurosci, London, EnglandImperial Coll London, Fac Med, Dept Brain Sci, Div Neurosci, London, England