The Impact of Stress, Microbial Dysbiosis, and Inflammation on Necrotizing Enterocolitis

被引：5

作者：

Yeramilli, Venkata ^{[1
]}

Cheddadi, Riadh ^{[1
]}

Benjamin, Heather ^{[1
]}

Martin, Colin ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Surg, Div Pediat, 1600 7th Ave S,Lowder Bldg,Suite 300, Birmingham, AL 35233 USA

来源：

MICROORGANISMS | 2023年 / 11卷 / 09期

关键词：

necrotizing enterocolitis; prenatal stress; cortisol; inflammation; microbiome; CYSTITIS/BLADDER PAIN SYNDROME; COMPLEMENT ACTIVATION PRODUCT; PRENATAL STRESS; PREMATURE-INFANT; MATERNAL STRESS; GUT MICROBIOME; PATHOGENESIS; EXPOSURE; CORTISOL; RISK;

D O I：

10.3390/microorganisms11092206

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Necrotizing enterocolitis (NEC) is the leading cause of intestinal morbidity and mortality in neonates. A large body of work exists; however, the pathogenesis of NEC remains poorly understood. Numerous predictors have been implicated in the development of NEC, with relatively less emphasis on maternal factors. Utilizing human tissue plays a crucial role in enhancing our comprehension of the underlying mechanisms accountable for this devastating disease. In this review, we will discuss how maternal stress affects the pathogenesis of NEC and how changes in the intestinal microbiome can influence the development of NEC. We will also discuss the results of transcriptomics-based studies and analyze the gene expression changes in NEC tissues and other molecular targets associated with the pathogenesis of NEC.

引用

页数：12